New Therapies and Strategies to Curb HIV Infections with a Focus on Macrophages and Reservoirs

被引：8

作者：

Marra, Maria ^{[1
]}

Catalano, Alessia ^{[2
]}

Sinicropi, Maria Stefania ^{[1
]}

Ceramella, Jessica ^{[1
]}

Iacopetta, Domenico ^{[1
]}

Salpini, Romina ^{[3
]}

Svicher, Valentina ^{[3
]}

Marsico, Stefania ^{[1
]}

Aquaro, Stefano ^{[1
]}

Pellegrino, Michele ^{[1
]}

机构：

[1] Univ Calabria, Dept Pharm Hlth & Nutr Sci, Via Pietro Bucci, I-87036 Arcavacata Di Rende, Italy

[2] Univ Bari Aldo Moro, Dept Pharm Drug Sci, I-70126 Bari, Italy

[3] Univ Tor Vergata, Dept Expt Med, I-00133 Rome, Italy

来源：

VIRUSES-BASEL | 2024年 / 16卷 / 09期

关键词：

cART; HAART; antiretroviral therapy; HIV; AIDS; macrophages; HIV reservoirs; reverse transcriptase inhibitors; protease inhibitors; entry inhibitors; integrase inhibitors; REVERSE-TRANSCRIPTASE INHIBITOR; RETROVIRUSES HTLV-III; ACYCLIC NUCLEOSIDE PHOSPHONATES; PROTEASE INHIBITORS; ANTIRETROVIRAL DRUGS; MONOCLONAL-ANTIBODY; IN-VITRO; HIV-1-INFECTED MACROPHAGES; PREEXPOSURE PROPHYLAXIS; CELLULAR RESERVOIRS;

D O I：

10.3390/v16091484

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

More than 80 million people worldwide have been infected with the human immunodeficiency virus (HIV). There are now approximately 39 million individuals living with HIV/acquired immunodeficiency syndrome (AIDS). Although treatments against HIV infection are available, AIDS remains a serious disease. Combination antiretroviral therapy (cART), also known as highly active antiretroviral therapy (HAART), consists of treatment with a combination of several antiretroviral drugs that block multiple stages in the virus replication cycle. However, the increasing usage of cART is inevitably associated with the emergence of HIV drug resistance. In addition, the development of persistent cellular reservoirs of latent HIV is a critical obstacle to viral eradication since viral rebound takes place once anti-retroviral therapy (ART) is interrupted. Thus, several efforts are being applied to new generations of drugs, vaccines and new types of cART. In this review, we summarize the antiviral therapies used for the treatment of HIV/AIDS, both as individual agents and as combination therapies, and highlight the role of both macrophages and HIV cellular reservoirs and the most recent clinical studies related to this disease.

引用

页数：43

共 303 条

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