Urea-based DES as an amine source to access nitrogen-containing heterocycles

被引：5

作者：

Suresh, Sundararajan ^{[1
]}

Khan, Fazlur Rahman Nawaz ^{[1
]}

机构：

[1] Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632 014, Tamil Nadu, India

来源：

TETRAHEDRON LETTERS | 2024年 / 148卷

关键词：

Deep Eutectic solvent; C-H Functionalization; Greener synthesis; Photophysical properties; Nitrogen heterocycles; DEEP EUTECTIC SOLVENTS; FUNCTIONALIZATION; DERIVATIVES; SYSTEMS; MEDIA;

D O I：

10.1016/j.tetlet.2024.155224

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report a urea-based DES that acts as an amine source in the synthesis of N-substituted styryl quinazolinone from anthranilic acid via N-acylation, cyclization, and subsequent sp3 C-H functionalization under a green reaction medium. The salient features of this approach are gram-scale synthesis, mild reaction conditions, and a metal-free methodology. Additionally, post-functionalization and photophysical properties were evaluated.

引用

页数：5

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