Urea-based DES as an amine source to access nitrogen-containing heterocycles

被引：5
|
作者：
Suresh, Sundararajan [1 ]
Khan, Fazlur Rahman Nawaz [1 ]
机构：
[1] Vellore Inst Technol, Sch Adv Sci, Organ & Med Chem Res Lab, Vellore 632 014, Tamil Nadu, India
来源：
TETRAHEDRON LETTERS | 2024年 / 148卷
关键词：
Deep Eutectic solvent; C-H Functionalization; Greener synthesis; Photophysical properties; Nitrogen heterocycles; DEEP EUTECTIC SOLVENTS; FUNCTIONALIZATION; DERIVATIVES; SYSTEMS; MEDIA;
D O I：
10.1016/j.tetlet.2024.155224
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein, we report a urea-based DES that acts as an amine source in the synthesis of N-substituted styryl quinazolinone from anthranilic acid via N-acylation, cyclization, and subsequent sp3 C-H functionalization under a green reaction medium. The salient features of this approach are gram-scale synthesis, mild reaction conditions, and a metal-free methodology. Additionally, post-functionalization and photophysical properties were evaluated.
引用
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页数：5
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