Emerging Trends in the Application of Extracellular Vesicles as Novel Oral Delivery Vehicles for Therapeutics in Inflammatory Diseases

被引：6

作者：

Zeng, Mingtang ^{[1
]}

Liu, Maozhu ^{[2
]}

Tao, Xuelin ^{[1
]}

Yin, Xi ^{[1
]}

Shen, Chao ^{[1
]}

Wang, Xueyan ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Pharm, Chengdu 610041, Peoples R China

[2] Sichuan Univ, West China Hosp, Ctr Infect Dis, Chengdu 610041, Peoples R China

来源：

INTERNATIONAL JOURNAL OF NANOMEDICINE | 2024年 / 19卷

关键词：

extracellular vesicles; anti-inflammatory; drug delivery systems; food; oral administration; OUTER-MEMBRANE VESICLES; EXOSOME-LIKE NANOPARTICLES; TARGETED DRUG-DELIVERY; MILK-DERIVED EXOSOMES; NANOVESICLES; MICRORNAS; COLITIS; BOVINE; CELLS; MOUSE;

D O I：

10.2147/IJN.S475532

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Inflammation involves complex immune responses where cytokines such as TNF-alpha, IL-1, and IL-6 promote vasodilation and increased vascular permeability to facilitate immune cell migration to inflammation sites. Persistent inflammation is linked to diseases like cancer, arthritis, and neurodegenerative disorders. Although oral anti-inflammatory drugs are favored for their non-invasiveness and costeffectiveness, their efficacy is often compromised due to gastrointestinal degradation and limited bioavailability. Recent advancements highlight the potential of extracellular vesicles (EVs) as nanocarriers that enhance drug delivery by encapsulating therapeutic agents, ensuring targeted release and reduced toxicity. These EVs, derived from dietary sources and cell cultures, exhibit excellent biocompatibility and stability, presenting a novel approach in anti-inflammatory therapies. This review discusses the classification and advantages of orally administered EVs (O-EVs), their mechanism of action, and their emerging role in treating inflammatory conditions, positioning them as promising vectors in the development of innovative anti-inflammatory drug delivery systems.

引用

页码：8573 / 8601

页数：29

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