Sporadic Occurrence of Ensitrelvir-Resistant SARS-CoV-2, Japan

被引：3

作者：

Doi, Akihiro ^{[1
]}

Ota, Masayuki ^{[1
]}

Saito, Masumichi ^{[1
]}

Matsuyama, Shutoku ^{[1
,2
]}

机构：

[1] Natl Inst Infect Dis, Tokyo, Japan

[2] ACEL Inc, Sagamihara, Kanagawa, Japan

来源：

EMERGING INFECTIOUS DISEASES | 2024年 / 30卷 / 06期

关键词：

D O I：

10.3201/eid3006.240023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using the GISAID EpiCoV database, we identified 256 COVID-19 patients in Japan during March 31–Decem-ber 31, 2023, who had mutations in the SARS-CoV-2 nonstructural protein 5 conferring ensitrelvir resistance. Ongoing genomic surveillance is required to monitor emergence of SARS-CoV-2 mutations that are resistant to anticoronaviral drugs. © 2024 Centers for Disease Control and Prevention (CDC). All rights reserved.

引用

页码：1289 / 1291

页数：3

共 10 条

[1] Frequent occurrence of mutations in nsp3 and nsp4 of SARS-CoV-2, presumably caused by the inhaled asthma drug ciclesonide [J].

Doi, Akihiro ;

Tomita, Yuriko ;

Okura, Hiyori ;

Matsuyama, Shutoku .

PNAS NEXUS, 2022, 1 (04)

[2] Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease [J].

Flynn, Julia M. ;

Huang, Qiu Yu J. ;

Zvornicanin, Sarah N. ;

Schneider-Nachum, Gila ;

Shaqra, Ala M. ;

Yilmaz, Nese Kurt ;

Moquin, Stephanie A. ;

Dovala, Dustin ;

Schiffer, Celia A. ;

Bolon, Daniel N. A. .

ACS INFECTIOUS DISEASES, 2023, 9 (07) :1372-1386

[3]

Japan Ministry of Health Labour and Welfare, Usage of drugs for the treatment of novel coronavirus infections

[4]

Japan National Institute of Infectious Diseases, Amino acid substitutions due to viral genomic mutations that may affect the efficacy of therapeutic drugs against the new coronavirus (SARS-CoV-2), V4th

[5] The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir [J].

Jochmans, Dirk ;

Liu, Cheng ;

Donckers, Kim ;

Stoycheva, Antitsa ;

Boland, Sandro ;

Stevens, Sarah K. ;

De Vita, Chloe ;

Vanmechelen, Bert ;

Maes, Piet ;

Trueb, Bettina ;

Ebert, Nadine ;

Thiel, Volker ;

De Jonghe, Steven ;

Vangeel, Laura ;

Bardiot, Dorothee ;

Jekle, Andreas ;

Blatt, Lawrence M. ;

Beigelman, Leonid ;

Symons, Julian A. ;

Raboisson, Pierre ;

Chaltin, Patrick ;

Marchand, Arnaud ;

Neyts, Johan ;

Deval, Jerome ;

Vandyck, Koen .

MBIO, 2023, 14 (01)

[6] In vitro and in vivo characterization of SARS-CoV-2 resistance to ensitrelvir [J].

Kiso, Maki ;

Yamayoshi, Seiya ;

Iida, Shun ;

Furusawa, Yuri ;

Hirata, Yuichiro ;

Uraki, Ryuta ;

Imai, Masaki ;

Suzuki, Tadaki ;

Kawaoka, Yoshihiro .

NATURE COMMUNICATIONS, 2023, 14 (01)

[7] Efficacy comparison of 3CL protease inhibitors ensitrelvir and nirmatrelvir against SARS-CoV-2 in vitro and in vivo [J].

Kuroda, Takayuki ;

Nobori, Haruaki ;

Fukao, Keita ;

Baba, Kaoru ;

Matsumoto, Kazumi ;

Yoshida, Shinpei ;

Tanaka, Yukari ;

Watari, Ryosuke ;

Oka, Ryoko ;

Kasai, Yasuyuki ;

Inoue, Kae ;

Kawashima, Sho ;

Shimba, Alice ;

Hayasaki-Kajiwara, Yoko ;

Tanimura, Miki ;

Zhang, Qianhui ;

Tachibana, Yuki ;

Kato, Teruhisa ;

Shishido, Takao .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2023, 78 (04) :946-952

[8] Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors [J].

Moghadasi, Seyed Arad ;

Heilmann, Emmanuel ;

Khalil, Ahmed Magdy ;

Nnabuife, Christina ;

Kearns, Fiona L. ;

Ye, Chengjin ;

Moraes, Sofia N. ;

Costacurta, Francesco ;

Esler, Morgan A. ;

Aihara, Hideki ;

von Laer, Dorothee ;

Martinez-Sobrido, Luis ;

Palzkill, Timothy ;

Amaro, Rommie E. ;

Harris, Reuben S. .

SCIENCE ADVANCES, 2023, 9 (13)

[9] Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main protease [J].

Noske, Gabriela Dias ;

Silva, Ellen de Souza ;

de Godoy, Mariana Ortiz ;

Dolci, Isabela ;

Fernandes, Rafaela Sachetto ;

Guido, Rafael Victorio Carvalho ;

Sjoe, Peter ;

Oliva, Glaucius ;

Godoy, Andre Schutzer .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (03)

[10] S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters [J].

Sasaki, Michihito ;

Tabata, Koshiro ;

Kishimoto, Mai ;

Itakura, Yukari ;

Kobayashi, Hiroko ;

Ariizumi, Takuma ;

Uemura, Kentaro ;

Toba, Shinsuke ;

Kusakabe, Shinji ;

Maruyama, Yuki ;

Iida, Shun ;

Nakajima, Noriko ;

Suzuki, Tadaki ;

Yoshida, Shinpei ;

Nobori, Haruaki ;

Sanaki, Takao ;

Kato, Teruhisa ;

Shishido, Takao ;

Hall, William W. ;

Orba, Yasuko ;

Sato, Akihiko ;

Sawa, Hirofumi .

SCIENCE TRANSLATIONAL MEDICINE, 2023, 15 (679)

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