Effectiveness and safety of steamed ginger extract on mild osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial

被引:0
作者
Baek, Hyang-Im [1 ,2 ]
Shen, Lei [3 ]
Ha, Ki-Chan [2 ]
Park, Yu Kyung [2 ]
Kim, Cha Soon [4 ]
Kwon, Jeong Eun [5 ]
Park, Soo Jung [6 ]
机构
[1] Woosuk Univ, Dept Food Sci & Nutr, Wonju 55338, South Korea
[2] Healthcare Claims & Management Inc, Jeonju, South Korea
[3] Aerosp Ctr Hosp, Beijing 100049, Peoples R China
[4] Genencell Co Ltd, Yongin 16950, South Korea
[5] Kyung Hee Univ, Dept Oriental Med Biotechnol, Yongin 17104, South Korea
[6] Woosuk Univ, Coll Korean Med, Dept Sasang Constitut Med, Jeonju 55338, South Korea
关键词
KNEE OSTEOARTHRITIS; ANTIOXIDANT; PAIN; SUPPLEMENTATION; BIOMARKERS; MANAGEMENT;
D O I
10.1039/d4fo01640h
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The purpose of this study was to evaluate the efficacy and safety of steamed ginger extract (GGE03) in subjects with mild knee osteoarthritis (OA). In total, 100 subjects were randomly assigned (1 : 1) to the GGE03 (0.48 g day-1 as GGE03) or placebo (0 g day-1 as GGE03) group and administered 1.6 g of the product for 12 weeks. Biomarkers were measured before and after intervention. At the efficacy endpoint, pain visual analog scale (VAS) Korean-Western Ontario and McMaster University Osteoarthritis Index (K-WOMAC; total scores, sub-scores) and patient global assessment (PGA) were found to be decreased in a statistically significantly manner in the GGE03 group compared to the placebo group. No significant changes were observed in any safety endpoint. These results suggest that GGE03 intake is useful as a functional food because it has beneficial effects in terms of improving joint pain as well as managing or preventing knee OA without side effects. The purpose of this study was to evaluate the efficacy and safety of steamed ginger extract (GGE03) in subjects with mild knee osteoarthritis (OA).
引用
收藏
页码:9512 / 9523
页数:12
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