Current development and structure-activity relationship study of berberine derivatives

被引：5

作者：

Luo, Xiong-Fei ^{[1
]}

Zhou, Han ^{[1
]}

Deng, Peng ^{[1
]}

Zhang, Shao-Yong ^{[2
]}

Wang, Yi-Rong ^{[1
]}

Ding, Yan-Yan ^{[1
]}

Wang, Guang-Han ^{[1
]}

Zhang, Zhi-Jun ^{[1
]}

Wu, Zheng-Rong ^{[1
]}

Liu, Ying-Qian ^{[1
,2
,3
]}

机构：

[1] Lanzhou Univ, Sch Pharm, Lanzhou 730000, Peoples R China

[2] Huzhou Univ, Coll Life Sci, Key Lab Vector Biol & Pathogen Control Zhejiang Pr, Huzhou 313000, Peoples R China

[3] Lanzhou Univ, State Key Lab Grassland Agroecosyst, Lanzhou 730000, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2024年 / 112卷

基金：

中国国家自然科学基金;

关键词：

Berberine; Structure-activity relationships; Structural modification; Biological activities; BIOLOGICAL EVALUATION; ANTIMICROBIAL ACTIVITY; BERBERRUBINE DERIVATIVES; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ALKALOID BERBERINE; QUADRUPLEX-DNA; AGENTS; DESIGN; DISCOVERY;

D O I：

10.1016/j.bmc.2024.117880

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Berberine is a quaternary ammonium isoquinoline alkaloid derived from traditional Chinese medicines Coptis chinensis and Phellodendron chinense. It has many pharmacological activities such as hypoglycemic, hypolipidemic, anti-tumor, antimicrobial and anti-inflammatory. Through structural modifications at various sites of berberine, the introduction of different groups can change berberine's physical and chemical properties, thereby improving the biological activity and clinical efficacy, and expanding the scope of application. This paper reviews the research progress and structure-activity relationships of berberine in recent years, aiming to provide valuable insights for the exploration of novel berberine derivatives.

引用

页数：16

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