New Advances in General Biomedical Applications of PAMAM Dendrimers

被引:185
作者
de Araujo, Renan Vinicius [1 ]
Santos, Soraya da Silva [1 ]
Ferreira, Elizabeth Igne [1 ]
Giarolla, Jeanine [1 ]
机构
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, Lab Design & Synth Chemotherapeut Potentially Act, 580 Bldg 13, BR-05508900 Sao Paulo, Brazil
基金
巴西圣保罗研究基金会;
关键词
PAMAM; dendrimers; drug delivery; gene delivery; nanotechnology; CALCIUM-PHOSPHATE NANOCOMPOSITE; EFFICIENT SIRNA DELIVERY; DRUG-DELIVERY; IN-VITRO; POLY(AMIDOAMINE) DENDRIMERS; POLYAMIDOAMINE DENDRIMERS; DENTIN REMINERALIZATION; PARKINSONS-DISEASE; ZEBRAFISH EMBRYOS; CATIONIC PAMAM;
D O I
10.3390/molecules23112849
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by Donald A. Tomalia, as a new class of polymers, named starburst polymers'. This important contribution of Professor Tomalia opened a new research field involving nanotechnological approaches. From then on, many groups have been using PAMAM for diverse applications in many areas, including biomedical applications. The possibility of either linking drugs and bioactive compounds, or entrapping them into the dendrimer frame can improve many relevant biological properties, such as bioavailability, solubility, and selectivity. Directing groups to reach selective delivery in a specific organ is one of the advanced applications of PAMAM. In this review, structural and safety aspects of PAMAM and its derivatives are discussed, and some relevant applications are briefly presented. Emphasis has been given to gene delivery and targeting drugs, as advanced delivery systems using PAMAM and an incentive for its use on neglected diseases are briefly mentioned.
引用
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页数:27
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