Exercise and brain health in patients with coronary artery disease: study protocol for the HEART-BRAIN randomized controlled trial

被引：2

作者：

Toval, Angel ^{[1
]}

Solis-Urra, Patricio ^{[1
,2
]}

Bakker, Esmee A. ^{[1
,3
]}

Sanchez-Aranda, Lucia ^{[1
]}

Fernandez-Ortega, Javier ^{[1
]}

Prieto, Carlos ^{[1
]}

Alonso-Cuenca, Rosa Maria ^{[1
,4
]}

Gonzalez-Garcia, Alberto ^{[5
]}

Martin-Fuentes, Isabel ^{[1
]}

Fernandez-Gamez, Beatriz ^{[1
]}

Olvera-Rojas, Marcos ^{[1
]}

Coca-Pulido, Andrea ^{[1
]}

Bellon, Dario ^{[1
]}

Sclafani, Alessandro ^{[1
]}

Sanchez-Martinez, Javier ^{[1
]}

Rivera-Lopez, Ricardo ^{[6
]}

Herrera-Gomez, Norberto ^{[1
,4
]}

Penafiel-Burkhardt, Rafael ^{[6
]}

Lopez-Espinosa, Victor ^{[6
]}

Corpas-Perez, Sara ^{[4
]}

Garcia-Ortega, Maria Belen ^{[6
]}

Vega-Cordoba, Alejandro ^{[6
]}

Barranco-Moreno, Emilio J. ^{[1
]}

Morales-Navarro, Francisco J. ^{[1
]}

Nieves, Raul ^{[1
]}

Caro-Rus, Alfredo ^{[1
]}

Amaro-Gahete, Francisco J. ^{[7
,8
,9
]}

Mora-Gonzalez, Jose ^{[1
]}

Vidal-Almela, Sol ^{[1
]}

Carlen, Anna ^{[1
,10
,11
]}

Migueles, Jairo H. ^{[1
]}

Erickson, Kirk I. ^{[12
]}

Moreno-Escobar, Eduardo ^{[4
,9
]}

Garcia-Orta, Rocio ^{[6
,9
]}

Esteban-Cornejo, Irene ^{[1
,8
,9
]}

Ortega, Francisco B. ^{[1
,8
,13
]}

机构：

[1] Univ Granada, Sport & Hlth Univ Res Inst iMUDS, Fac Sport Sci, Dept Phys Educ & Sports, Granada, Spain

[2] Univ Andres Bello, Fac Educ & Social Sci, Vina Del Mar, Chile

[3] Radboud Univ Nijmegen, Med Ctr, Dept Primary & Community Care, Nijmegen, Netherlands

[4] San Cecilio Clin Univ Hosp, Cardiol Serv, Granada, Spain

[5] Univ Granada, Fac Hlth Sci, Dept Nursing, Granada, Spain

[6] Virgen Nieves Univ Hosp, Cardiol Serv, Granada, Spain

[7] Univ Granada, Fac Med, Dept Physiol, Granada, Spain

[8] Inst Salud Carlos III, CIBER Fisiopatol Obes & Nutr CIBEROBN, Granada, Spain

[9] GRANADA, Inst Invest Biosanit ibs, Granada, Spain

[10] Linkoping Univ, Dept Clin Physiol Linkoping, Linkoping, Sweden

[11] Linkoping Univ, Dept Hlth Med & Caring Sci, Linkoping, Sweden

[12] AdventHealth Res Inst, Neurosci, Orlando, FL USA

[13] Univ Jyvaskyla, Fac Sport & Hlth Sci, Jyvaskyla, Finland

来源：

FRONTIERS IN AGING NEUROSCIENCE | 2024年 / 16卷

关键词：

ischemic disease; coronary heart disease; cerebral blood flow; cognition; executive function; fitness; HIIT; resistance training (RT); QUALITY-OF-LIFE; CARDIAC REHABILITATION; PHYSICAL-ACTIVITY; SPANISH VERSION; CARDIORESPIRATORY FITNESS; AEROBIC EXERCISE; PERFUSION MRI; GUIDELINES; SCALE; RISK;

D O I：

10.3389/fnagi.2024.1437567

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Introduction Patients with coronary artery disease (CAD) have a higher risk of developing cognitive impairment and mental health disorders compared to the general population. Physical exercise might improve their brain health. The overall goal of the HEART-BRAIN randomized controlled trial (RCT) is to investigate the effects of different types of exercise on brain health outcomes in patients with CAD, and the underlying mechanisms. Methods This three-arm, single-blinded RCT will include 90 patients with CAD (50-75 years). Participants will be randomized into: (1) control group-usual care (n = 30), (2) aerobic high-intensity interval training (HIIT) (n = 30), or (3) HIIT combined with resistance exercise training (n = 30). The 12-week intervention includes 3 supervised sessions (45-min each) per week for the exercise groups. Outcomes will be assessed at baseline and post-intervention. The primary outcome is to determine changes in cerebral blood flow assessed by magnetic resonance imaging. Secondary outcomes include changes in brain vascularization, cognitive measures (i.e., general cognition, executive function and episodic memory), and cardiorespiratory fitness. Additional health-related outcomes, and several potential mediators and moderators will be investigated (i.e., brain structure and function, cardiovascular and brain-based biomarkers, hemodynamics, physical function, body composition, mental health, and lifestyle behavior). Conclusion The HEART-BRAIN RCT will provide novel insights on how exercise can impact brain health in patients with CAD and the potential mechanisms explaining the heart-brain connection, such as changes in cerebral blood flow. The results may have important clinical implications by increasing the evidence on the effectiveness of exercise-based strategies to delay cognitive decline in this high-risk population.

引用

页数：17

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