Dataset factors associated with age-related changes in brain structure and function in neurodevelopmental conditions

被引：0

作者：

Vandewouw, Marlee M. ^{[1
,2
]}

Ye, Yifan ^{[1
,3
]}

Crosbie, Jennifer ^{[4
,5
]}

Schachar, Russell J. ^{[4
,5
]}

Iaboni, Alana ^{[1
]}

Georgiades, Stelios ^{[6
]}

Nicolson, Robert ^{[7
]}

Kelley, Elizabeth ^{[8
,9
,10
]}

Ayub, Muhammad ^{[10
,11
]}

Jones, Jessica ^{[8
,9
,10
]}

Arnold, Paul D. ^{[12
]}

Taylor, Margot J. ^{[13
,14
,15
,16
]}

Lerch, Jason P. ^{[14
,17
,18
]}

Anagnostou, Evdokia ^{[1
,14
,19
]}

Kushki, Azadeh ^{[1
,2
]}

机构：

[1] Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Autism Res Ctr, Toronto, ON, Canada

[2] Univ Toronto, Inst Biomed Engn, Toronto, ON, Canada

[3] Univ Toronto, Div Engn Sci, Toronto, ON, Canada

[4] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[5] Hosp Sick Children, Dept Psychiat, Toronto, ON, Canada

[6] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

[7] Western Univ, Dept Psychiat, London, ON, Canada

[8] Queens Univ, Dept Psychol, Kingston, ON, Canada

[9] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada

[10] Queens Univ, Dept Psychiat, Kingston, ON, Canada

[11] UCL, Div Psychiat, London, England

[12] Univ Calgary, Mathison Ctr Mental Hlth Res & Educ, Cumming Sch Med, Calgary, AB, Canada

[13] Hosp Sick Children, Dept Diagnost & Intervent Radiol, Toronto, ON, Canada

[14] Hosp Sick Children, Program Neurosci & Mental Hlth, Toronto, ON, Canada

[15] Univ Toronto, Dept Psychol, Toronto, ON, Canada

[16] Univ Toronto, Dept Med Imaging, Toronto, ON, Canada

[17] Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Nuffield Dept Clin Neurosci, FMRIB, Oxford, England

[18] Univ Toronto, Dept Med Biophys, Toronto, ON, Canada

[19] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

来源：

HUMAN BRAIN MAPPING | 2024年 / 45卷 / 13期

关键词：

brain function; brain structure; consistency; development; large-scale datasets; AUTOMATED 3-D EXTRACTION; CORTICAL THICKNESS; SURFACE-AREA; MOTION ARTIFACT; CEREBRAL-CORTEX; ADOLESCENCE; CHILDHOOD; VOLUME; MULTISAMPLE; VALIDATION;

D O I：

10.1002/hbm.26815

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

With brain structure and function undergoing complex changes throughout childhood and adolescence, age is a critical consideration in neuroimaging studies, particularly for those of individuals with neurodevelopmental conditions. However, despite the increasing use of large, consortium-based datasets to examine brain structure and function in neurotypical and neurodivergent populations, it is unclear whether age-related changes are consistent between datasets and whether inconsistencies related to differences in sample characteristics, such as demographics and phenotypic features, exist. To address this, we built models of age-related changes of brain structure (regional cortical thickness and regional surface area; N = 1218) and function (resting-state functional connectivity strength; N = 1254) in two neurodiverse datasets: the Province of Ontario Neurodevelopmental Network and the Healthy Brain Network. We examined whether deviations from these models differed between the datasets, and explored whether these deviations were associated with demographic and clinical variables. We found significant differences between the two datasets for measures of cortical surface area and functional connectivity strength throughout the brain. For regional measures of cortical surface area, the patterns of differences were associated with race/ethnicity, while for functional connectivity strength, positive associations were observed with head motion. Our findings highlight that patterns of age-related changes in the brain may be influenced by demographic and phenotypic characteristics, and thus future studies should consider these when examining or controlling for age effects in analyses. Age-related changes in brain structure and function are not consistent between datasets of children and adolescents with neurodevelopmental conditions; these inconsistencies may be influenced by sociodemographic and acquisition variables.image

引用

页数：15

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