Improving the Photodynamic Activity of Water-Soluble Porphyrin-Polysaccharide Complexes by Folic Acid Modification

被引：1

作者：

Nishimura, Kotaro ^{[1
]}

Kono, Nanami ^{[1
]}

Oshige, Ayano ^{[1
]}

Takahashi, Haruko ^{[2
]}

Yamana, Keita ^{[1
]}

Kawasaki, Riku ^{[1
]}

Ikeda, Atsushi ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Adv Sci & Engn, Appl Chem Program, 1-4-1 Kagamiyama, Higashihiroshima, Hiroshima 7398527, Japan

[2] Hiroshima Univ, Grad Sch Integrated Sci Life, Program Basic Biol, 1-3-1 Kagamiyama, Higashihiroshima, Hiroshima 7398526, Japan

来源：

CHEMMEDCHEM | 2024年 / 19卷 / 20期

基金：

日本科学技术振兴机构;

关键词：

Folic acids; Supramolecular chemistry; Photodynamic therapy; Polysaccharides; Porphyrinoids; MACROMOLECULAR THERAPEUTICS; DRUG-DELIVERY; THERAPY; CANCER;

D O I：

10.1002/cmdc.202400268

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Studies have shown that folate receptors are highly expressed in various cancer cells. Here, we synthesized folic acid-conjugated pullulan (FAPL) as a solubilizing agent to improve the photodynamic activity of porphyrin derivative-polysaccharide complexes. The porphyrin derivative-FAPL complex exhibited long-term stability in an aqueous solution, attributed to the folic acid modification. Furthermore, in vitro and in vivo experiments highlighted the enhanced photodynamic activity of the porphyrin derivative-FAPL complex toward 4T1 breast-cancer cells, compared with the activities of the porphyrin derivative-pullulan complex and Photofrin. This enhanced activity is attributed to the improvement of intracellular uptake by the folate receptor. The photodynamic activity of the porphyrin derivative-folic acid-conjugated pullulan complex was higher than those of the porphyrin derivative-pullulan complex and Photofrin during in vitro and in vivo experiments, due to the improvement of its intracellular uptake by the folate receptor. image

引用

页数：8

共 35 条

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