Drug Delivery Strategies for Age-Related Diseases

被引：0
作者：
Yoshihara, Kenichi [1 ]
Horiguchi, Michiko [1 ]
机构：
[1] Sanyo Onoda City Univ, Fac Pharmaceut Sci, Div Pharmaceut, 1-1-1 Daigaku Dori, Sanyo Onoda 7560884, Japan
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2024年 / 25卷 / 16期
关键词：
drug delivery systems; age-related diseases; p16(INK4A); SASP; senescence-associated beta-galactosidase; SENESCENT CELLS; IDENTIFICATION; LIGANDS;
D O I：
10.3390/ijms25168693
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Drug delivery systems (DDSs) enable the controlled release of drugs in the body. DDSs have attracted increasing attention for the treatment of various disorders, including cancer, inflammatory diseases, and age-related diseases. With recent advancements in our understanding of the molecular mechanisms of aging, new target molecules and drug delivery carriers for age-related diseases have been reported. In this review, we will summarize the recent research on DDSs for age-related diseases and identify DDS strategies in the treatment of age-related diseases.
引用
收藏
页数：23
相关论文
共 59 条
  • [1] Bioreversible Anionic Cloaking Enables Intracellular Protein Delivery with Ionizable Lipid Nanoparticles
    Alamgir, Azmain
    Ghosal, Souvik
    DeLisa, Matthew P.
    Alabi, Christopher A.
    [J]. ACS CENTRAL SCIENCE, 2024, 10 (06) : 1179 - 1190
  • [2] Characterization of novel markers of senescence and their prognostic potential in cancer
    Althubiti, M.
    Lezina, L.
    Carrera, S.
    Jukes-Jones, R.
    Giblett, S. M.
    Antonov, A.
    Barlev, N.
    Saldanha, G. S.
    Pritchard, C. A.
    Cain, K.
    Macip, S.
    [J]. CELL DEATH & DISEASE, 2014, 5 : e1528 - e1528
  • [3] Senolytic CAR T cells reverse senescence-associated pathologies
    Amor, Corina
    Feucht, Judith
    Leibold, Josef
    Ho, Yu-Jui
    Zhu, Changyu
    Alonso-Curbelo, Direna
    Mansilla-Soto, Jorge
    Boyer, Jacob A.
    Li, Xiang
    Giavridis, Theodoros
    Kulick, Amanda
    Houlihan, Shauna
    Peerschke, Ellinor
    Friedman, Scott L.
    Ponomarev, Vladimir
    Piersigilli, Alessandra
    Sadelain, Michel
    Lowe, Scott W.
    [J]. NATURE, 2020, 583 (7814) : 127 - +
  • [4] Spheroplexes: Hybrid PLGA-cationic lipid nanoparticles, for in vitro and oral delivery of siRNA
    Arruda, Danielle Campiol
    Lachages, Anne-Marie
    Demory, Helene
    Escriou, Guillaume
    Lai-Kuen, Rene
    Dugas, Pierre-Yves
    Hoffmann, Celine
    Bessoles, Stephanie
    Sarrabayrouse, Guillaume
    Malachias, Angelo
    Finet, Stephanie
    Gastelois, Pedro Lana
    de Almeida Macedo, Waldemar Augusto
    Cunha, Armando da Silva, Jr.
    Bigey, Pascal
    Escriou, Virginie
    [J]. JOURNAL OF CONTROLLED RELEASE, 2022, 350 : 228 - 243
  • [5] 3D printed multi-drug-loaded suppositories for acute severe ulcerative colitis
    Awad, Atheer
    Hollis, Eleanor
    Goyanes, Alvaro
    Orlu, Mine
    Gaisford, Simon
    Basit, Abdul W.
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS-X, 2023, 5
  • [6] Chronic inflammation and the hallmarks of aging
    Baechle, Jordan J.
    Chen, Nan
    Makhijani, Priya
    Winer, Shawn
    Furman, David
    Winer, Daniel A.
    [J]. MOLECULAR METABOLISM, 2023, 74
  • [7] SANRA-a scale for the quality assessment of narrative review articles
    Baethge, Christopher
    Goldbeck-Wood, Sandra
    Mertens, Stephan
    [J]. RESEARCH INTEGRITY AND PEER REVIEW, 2019, 4 (01)
  • [8] Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
    Baker, Darren J.
    Childs, Bennett G.
    Durik, Matej
    Wijers, Melinde E.
    Sieben, Cynthia J.
    Zhong, Jian
    Saltness, Rachel A.
    Jeganathan, Karthik B.
    Verzosa, Grace Casaclang
    Pezeshki, Abdulmohammad
    Khazaie, Khashayarsha
    Miller, Jordan D.
    van Deursen, Jan M.
    [J]. NATURE, 2016, 530 (7589) : 184 - +
  • [9] Senescence and the SASP: many therapeutic avenues
    Birch, Jodie
    Gil, Jesus
    [J]. GENES & DEVELOPMENT, 2020, 34 (23-24) : 1565 - 1576
  • [10] Transcriptome signature of cellular senescence
    Casella, Gabriel
    Munk, Rachel
    Kim, Kyoung Mi
    Piao, Yulan
    De, Supriyo
    Abdelmohsen, Kotb
    Gorospe, Myriam
    [J]. NUCLEIC ACIDS RESEARCH, 2019, 47 (14) : 7294 - 7305
123456