GATA3 and TGF-(3 in normal placenta and pre-eclampsia

被引：2

作者：

Perna, Angelica ^{[1
]}

Hay, Eleonora ^{[2
]}

Lucariello, Angela ^{[3
]}

Scala, Beatrice ^{[2
]}

De Blasiis, Paolo ^{[2
]}

Komici, Klara ^{[1
]}

Sgambati, Eleonora ^{[4
]}

Guerra, Germano ^{[1
]}

Baldi, Alfonso ^{[5
]}

De Luca, Antonio ^{[2
]}

机构：

[1] Univ Molise, Dept Med & Hlth Sci Vincenzo Tiberio, I-86100 Campobasso, Italy

[2] Univ Campania Luigi Vanvitelli, Dept Mental & Phys Hlth & Prevent Med, Sect Human Anat, I-80138 Naples, Italy

[3] Univ Naples Parthenope, Dept Sport Sci & Wellness, I-80133 Naples, Italy

[4] Univ Molise, Dept Biosci & Terr, I-86090 Isernia, Italy

[5] Univ Campania Luigi Vanvitelli, Dept Environm Biol & Pharmaceut Sci & Technol, I-81100 Caserta, Italy

来源：

TISSUE & CELL | 2024年 / 88卷

关键词：

Placenta; Pre-eclampsia; Immunohistochemistry; GATA3; TGF-(3; EXPRESSION; DIFFERENTIATION; GENE;

D O I：

10.1016/j.tice.2024.102402

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

GATA3 plays critical roles in the development and function of various tissues and organs throughout the body. Likewise, TGF-(3 signaling is critical for placental development and can interact with GATA3. We aimed to investigate the involvement of the multifunctional cytokine and transcription factor in trophoblast development. By using immunohistochemistry, we evaluated the localization and expression level of GATA3 and TGF-(3 in placentas at term of normal pregnancy and with pre-eclampsia. Up-regulation of both GATA3 and TGF-(3 was observed in pathological placentas, with localization in the villus epithelium (syncytiotrophoblast) stroma and decidua. Our data show altered expression of TGF-(3 and GATA3, which downstream could lead to a cascade of events that negatively influence trophoblast development and contribute to the pathogenesis of pre-eclampsia.

引用

页数：6

共 33 条

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