Photocatalytic α-Difluoroalkoxyketones Synthesis via Radical Intermolecular Alkoxylation of Difluoroenol Silyl Ethers

被引：5

作者：

Paut, Julien ^{[1
,2
]}

Baldon, Simone ^{[2
]}

Anselmi, Elsa ^{[1
,3
]}

Dell'Amico, Luca ^{[2
]}

Dagousset, Guillaume ^{[1
]}

Magnier, Emmanuel ^{[1
]}

机构：

[1] Univ Paris Saclay, Inst Lavoisier Versailles, 45 Ave Etats Unis, F-78035 Versailles, France

[2] Univ Padua, Dept Chem Sci, Via Francesco Marzolo 1, I-35131 Padua, Italy

[3] Univ Tours, Fac Sci & Tech, F-37200 Tours, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2024年 / 366卷 / 16期

基金：

欧洲研究理事会;

关键词：

alpha-Difluoroalkoxyketones; Pyridinium salts; Photoredox catalysis; Difluoroenol silyl ethers; EDA complex;

D O I：

10.1002/adsc.202400510

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We present a metal-free photocatalytic approach for the synthesis of difluoroalkoxylatedketones. This strategy involves the generation of alkoxyl radicals from pyridinium salts upon the activity of a catalytic electron-donor-acceptor (EDA) complex. This mild process tolerates several functional groups and can be scaled up to gram scale. Diverse products manipulations accounts for the versatility of the obtained fluorinated products, highlighting the synthetic usefulness of this method. image

引用

页码：3500 / 3504

页数：5

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