Pretreatment with oleuropein protects the neonatal brain from hypoxia-ischemia by inhibiting apoptosis and neuroinflammation

被引:3
作者
Reyes-Corral, Marta [1 ]
Gil-Gonzalez, Laura [1 ]
Gonzalez-Diaz, Angela [1 ]
Tovar-Luzon, Javier [1 ]
Ayuso, Maria Irene [1 ,2 ]
Lao-Perez, Miguel [1 ]
Montaner, Joan [1 ,3 ]
de la Puerta, Rocio [4 ]
Fernandez-Torres, Rut [5 ]
Ybot-Gonzalez, Patricia [1 ,6 ]
机构
[1] CSIC US Junta Andalucia SAS, Inst Biomed Seville IBiS, Seville, Spain
[2] Spanish Network Res Mental Hlth, CIBERSAM, ISCIII, Seville, Spain
[3] Virgen Macarena Univ Hosp, Dept Neurol, Seville, Spain
[4] Univ Seville, Fac Farm, Dept Farmacol, Calle Prof Garcia Gonzalez 2, Seville 41012, Spain
[5] Univ Seville, Fac Quim, Dept Quim Analit, Calle Prof Garcia Gonzalez 1, Seville 41012, Spain
[6] CSIC, Madrid, Spain
关键词
Microglia; neonatal hypoxia-ischemia; neuroprotection; oleuropein; white matter injury; OLIVE LEAF EXTRACT; CEREBRAL ISCHEMIA/REPERFUSION; OLIGODENDROCYTE PROGENITORS; COGNITIVE DEFICITS; OXIDATIVE STRESS; DOUBLE-BLIND; INJURY; RAT; HYDROXYTYROSOL; OIL;
D O I
10.1177/0271678X241270237
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hypoxic-ischemic (HI) encephalopathy is a cerebrovascular injury caused by oxygen deprivation to the brain and remains a major cause of neonatal mortality and morbidity worldwide. Therapeutic hypothermia is the current standard of care but it does not provide complete neuroprotection. Our aim was to investigate the neuroprotective effect of oleuropein (Ole) in a neonatal (seven-day-old) mouse model of HI. Ole, a secoiridoid found in olive leaves, has previously shown to reduce damage against cerebral and other ischemia/reperfusion injuries. Here, we administered Ole as a pretreatment prior to HI induction at 20 or 100 mg/kg. A week after HI, Ole significantly reduced the infarct area and the histological damage as well as white matter injury, by preserving myelination, microglial activation and the astroglial reactive response. Twenty-four hours after HI, Ole reduced the overexpression of caspase-3 and the proinflammatory cytokines IL-6 and TNF-alpha. Moreover, using UPLC-MS/MS we found that maternal supplementation with Ole during pregnancy and/or lactation led to the accumulation of its metabolite hydroxytyrosol in the brains of the offspring. Overall, our results indicate that pretreatment with Ole confers neuroprotection and can prevent HI-induced brain damage by modulating apoptosis and neuroinflammation.
引用
收藏
页码:717 / 734
页数:18
相关论文
共 50 条
[41]   Dexmedetomidine Postconditioning Reduces Brain Injury after Brain Hypoxia-Ischemia in Neonatal Rats [J].
Ren, Xiaoyan ;
Ma, Hong ;
Zuo, Zhiyi .
JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2016, 11 (02) :238-247
[42]   Treatment with RNase alleviates brain injury but not neuroinflammation in neonatal hypoxia/ischemia [J].
Anderberg, Rozita H. ;
Andersson, E. Axel ;
Bucher, Valentina ;
Preissner, Klaus T. ;
Mallard, Carina ;
Joakim, Ek. C. .
JOURNAL OF NEUROSCIENCE RESEARCH, 2024, 102 (04)
[43]   Novel Injury Scoring Tool for Assessing Brain Injury following Neonatal Hypoxia-Ischemia in Mice [J].
Ozaydin, Burak ;
Bicki, Ela ;
Taparli, Onur E. ;
Sheikh, Temour Z. ;
Schmidt, Danielle K. ;
Yapici, Sefer ;
Hackett, Margarett B. ;
Karahan-Keles, Nida ;
Eickhoff, Jens C. ;
Corcoran, Karson ;
Lagoa-Miguel, Claudia ;
Guerrero Gonzalez, Jose ;
Dean III, Douglas C. ;
Sousa, Andre M. M. ;
Ferrazzano, Peter A. ;
Levine, Jon E. ;
Cengiz, Pelin .
DEVELOPMENTAL NEUROSCIENCE, 2022, 44 (4-5) :394-411
[44]   Effects of maternal separation on behavior and brain damage in adult rats exposed to neonatal hypoxia-ischemia [J].
Tata, Despina A. ;
Markostamou, Ioanna ;
Ioannidis, Anestis ;
Gkioka, Mara ;
Simeonidou, Constantina ;
Anogianakis, Georgios ;
Spandou, Evangelia .
BEHAVIOURAL BRAIN RESEARCH, 2015, 280 :51-61
[45]   Lactate Administration Reduces Brain Injury and Ameliorates Behavioral Outcomes Following Neonatal Hypoxia-Ischemia [J].
Tassinari, Isadora D'Avila ;
Galvan Andrade, Mirella Kielek ;
da Rosa, Luciana Abreu ;
Muller Hoff, Mariana Leivas ;
Nunes, Ricardo Ribeiro ;
Vogt, Everton Lopes ;
Fabres, Rafael Bandeira ;
Sanches, Eduardo Farias ;
Netto, Carlos Alexandre ;
Paz, Ana Helena ;
de Fraga, Luciano Sturmer .
NEUROSCIENCE, 2020, 448 :191-205
[46]   Neuronal Cell Death in Neonatal Hypoxia-Ischemia [J].
Northington, Frances J. ;
Chavez-Valdez, Raul ;
Martin, Lee J. .
ANNALS OF NEUROLOGY, 2011, 69 (05) :743-758
[47]   Sexually Dimorphic Outcomes after Neonatal Stroke and Hypoxia-Ischemia [J].
Charriaut-Marlangue, Christiane ;
Besson, Valerie C. ;
Baud, Olivier .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (01)
[48]   Inhaled Nitric Oxide Protects Males But not Females from Neonatal Mouse Hypoxia–Ischemia Brain Injury [J].
Changlian Zhu ;
Yanyan Sun ;
Jianfeng Gao ;
Xiaoyang Wang ;
Nikolaus Plesnila ;
Klas Blomgren .
Translational Stroke Research, 2013, 4 :201-207
[49]   Maternal alcoholism and neonatal hypoxia-ischemia: Neuroprotection by stilbenoid polyphenols [J].
Dumont, Ursule ;
Sanchez, Stephane ;
Olivier, Benjamin ;
Chateil, Jean-Francois ;
Deffieux, Denis ;
Quideau, Stephane ;
Pellerin, Luc ;
Beauvieux, Marie-Christine ;
Bouzier-Sore, Anne-Karine ;
Roumes, Helene .
BRAIN RESEARCH, 2020, 1738
[50]   Sevoflurane postconditioning provides neuroprotection against brain hypoxia-ischemia in neonatal rats [J].
Ren, Xiaoyan ;
Wang, Zhi ;
Ma, Hong ;
Zuo, Zhiyi .
NEUROLOGICAL SCIENCES, 2014, 35 (09) :1401-1404