Overcoming drug-resistant tumors with selection gene drives

被引：0
|
作者：
Wang, Hui [1 ]
Xie, Mingqi [2 ,3 ,4 ,5 ]
机构：
[1] Zhejiang Lab, Res Ctr Life Sci Comp, Hangzhou 311100, Zhejiang, Peoples R China
[2] Westlake Univ, Sch Med, Hangzhou 310024, Zhejiang, Peoples R China
[3] Westlake Lab Life Sci & Biomed, Hangzhou 310024, Zhejiang, Peoples R China
[4] Westlake Univ, Sch Life Sci, Key Lab Growth Regulat & Translat Res Zhejiang Pro, Hangzhou 310024, Zhejiang, Peoples R China
[5] Westlake Univ, Sch Engn, Hangzhou 310030, Zhejiang, Peoples R China
来源：
CELL GENOMICS | 2024年 / 4卷 / 09期
基金：
中国国家自然科学基金;
关键词：
I CLINICAL-TRIAL; THERAPY; CANCER; EVOLUTION;
D O I：
10.1016/j.xgen.2024.100653
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Drug resistance is a major hurdle prohibiting effective treatment of many diseases, including cancer. Using model-guided designs, Leighow et al.(1) engineered a dual-switch selection gene drive system custom designed to combat drug-resistant tumors. By demonstrating remarkable killing efficacies in preclinical models using human non-small lung cancer cells in vitro and in mice, this work describes an attractive mindset to develop next-generation anticancer therapies.
引用
收藏
页数：3
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