Solid-state nanochannels based on electro-optical dual signals for detection of analytes

The sensitive detection of analytes of different sizes is crucial significance for environmental protection, food safety and medical diagnostics. The confined space of nanochannels provides a location closest to the molecular reaction behaviors in real systems, thereby opening new opportunities for the precise detection of analytes. However, due to the susceptibility to external interference on the confined space of nanochannels, the high sensitivity nature of the current signals through the nanochannels is more troubling for the detection reliability. Combining highly sensitive optical signals with the sensitive current signals of solid-state nanochannels establishes a nanochannel detection platform based on electro-optical dual signals, potentially offering more sensitive, specific, and accuracy detection of analytes. This review summarizes the last five years of applications of solidstate nanochannels based on electro-optical dual signals in analytes detection. Firstly, the detection principles of solid-state nanochannels and the construction strategies of nanochannel electro-optical sensing platforms are discussed. Subsequently, the review comprehensively outlines the applications involving nanochannels with electrical signals combined with fluorescence signals, electrical signals combined with surface-enhanced Raman spectroscopy signals, and electrical signals combined with other optical signals in analyte detection. Additionally, the perspectives and difficulties of nanochannels are investigated on the basis of electro-optical dual signals.