Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016-2023

被引：0

作者：

Yamada, Yutaka ^{[1
]}

Imaoka, Tatsuhiko ^{[1
]}

Iwasaki, Toshiyasu ^{[2
]}

Kobayashi, Junya ^{[3
]}

Misumi, Munechika ^{[4
]}

Sakai, Kazuo ^{[5
]}

Sugihara, Takashi ^{[6
]}

Suzuki, Keiji ^{[7
]}

Tauchi, Hiroshi ^{[8
]}

Yasuda, Hiroshi ^{[9
]}

Yoshinaga, Shinji ^{[10
]}

Sasatani, Megumi ^{[11
]}

Tanaka, Satoshi ^{[6
]}

Doi, Kazutaka ^{[12
]}

Tomita, Masanori ^{[2
]}

Iizuka, Daisuke ^{[1
]}

Kakinuma, Shizuko ^{[1
]}

Sasaki, Michiya ^{[2
]}

Kai, Michiaki ^{[13
]}

机构：

[1] Natl Inst Quantum Sci & Technol, Inst Radiol Sci, Dept Radiat Effects Res, 4-9-1 Anagawa,Inage Ku, Chiba 2638555, Japan

[2] Cent Res Inst Elect Power Ind, Sustainable Syst Res Lab, 1646 Abiko, Abiko, Chiba 2701194, Japan

[3] Int Univ Hlth & Welf, Sch Hlth Sci Narita, Dept Radiol Sci, 4-3 Kozunomori, Narita, Chiba 2868686, Japan

[4] Radiat Effects Res Fdn, Dept Stat, 5-2 Hijiyama Pk,Minami Ku, Hiroshima 7320815, Japan

[5] Tokyo Healthcare Univ, 2-5-1 Higashigaoka,Meguro Ku, Tokyo 1528558, Japan

[6] Inst Environm Sci, Dept Radiobiol, 1-7 Ienomae, Rokkasho, Aomori 0393212, Japan

[7] Nagasaki Univ, Atom Bomb Dis Inst, Dept Radiat Med Sci, 1-12-4 Sakamoto, Nagasaki 8528523, Japan

[8] Ibaraki Univ, Dept Environm Sci, Bunkyo 2-1-1, Mito, Ibaraki 3108512, Japan

[9] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Radiat Biophys, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348553, Japan

[10] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Environmetr & Biometr, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348553, Japan

[11] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Expt Oncol, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348553, Japan

[12] Natl Inst Quantum Sci & Technol, Inst Radiol Sci, Dept Radiat Regulatory Sci Res, 4-9-1 Anagawa,Inage Ku, Chiba 2638555, Japan

[13] Nippon Bunri Univ, 1727-162 Ichiki, Oita, Oita 8700397, Japan

来源：

JOURNAL OF RADIATION RESEARCH | 2024年 / 65卷 / 05期

关键词：

radiation; low dose; low dose rate; biology; modeling; ATOMIC-BOMB SURVIVORS; RAT MAMMARY CARCINOGENESIS; CANCER INCIDENCE; LIFE-SPAN; EXTRAPOLATION FACTORS; MICE; MORTALITY; EXPOSURE; RISK; GENOME;

D O I：

10.1093/jrr/rrae049

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Planning and Acting Network for Low Dose Radiation Research in Japan (PLANET) was established in 2017 in response to the need for an all-Japan network of experts. It serves as an academic platform to propose strategies and facilitate collaboration to improve quantitative estimation of health risks from ionizing radiation at low-doses and low-dose-rates. PLANET established Working Group 1 (Dose-Rate Effects in Animal Experiments) to consolidate findings from animal experiments on dose-rate effects in carcinogenesis. Considering international trends in this field as well as the situation in Japan, PLANET updated its priority research areas for Japanese low-dose radiation research in 2023 to include (i) characterization of low-dose and low-dose-rate radiation risk, (ii) factors to be considered for individualization of radiation risk, (iii) biological mechanisms of low-dose and low-dose-rate radiation effects and (iv) integration of epidemiology and biology. In this context, PLANET established Working Group 2 (Dose and Dose-Rate Mapping for Radiation Risk Studies) to identify the range of doses and dose rates at which observable effects on different endpoints have been reported; Working Group 3 (Species- and Organ-Specific Dose-Rate Effects) to consider the relevance of stem cell dynamics in radiation carcinogenesis of different species and organs; and Working Group 4 (Research Mapping for Radiation-Related Carcinogenesis) to sort out relevant studies, including those on non-mutagenic effects, and to identify priority research areas. These PLANET activities will be used to improve the risk assessment and to contribute to the revision of the next main recommendations of the International Commission on Radiological Protection.

引用

页码：561 / 574

页数：14