Von Willebrand Factor Dynamics in Patients with Aortic Stenosis Undergoing Surgical and Transcatheter Valve Replacement

被引:0
|
作者
Grigorescu, Andrei Emanuel [1 ,2 ,3 ,4 ]
Anghel, Andrei [5 ]
Koch, Claudia [5 ]
Horhat, Florin George [6 ,7 ]
Savescu, Delia [8 ]
Feier, Horea [1 ,2 ,3 ]
机构
[1] Victor Babes Univ Med & Pharm Timisoara, Dept Cardiol, Timisoara 300041, Romania
[2] Inst Cardiovasc & Heart Dis Timisoara, Res Ctr, Timisoara 300310, Romania
[3] Inst Cardiovasc Dis, Div Cardiovasc Surg, Timisoara 300391, Romania
[4] Victor Babes Univ Med & Pharm Timisoara, Doctoral Sch Med Pharm, Timisoara 300041, Romania
[5] Victor Babes Univ Med & Pharm Timisoara, Dept Biochem, Timisoara 300041, Romania
[6] Victor Babes Univ Med & Pharm Timisoara, Ctr Translat Res & Syst Med, Timisoara 300041, Romania
[7] Victor Babes Univ Med & Pharm, Multidisciplinary Res Ctr Antimicrobial Resistance, Dept Microbiol, Timisoara 300041, Romania
[8] Childrens Emergency Hosp Louis Turcanu, Dept Lab, Timisoara, Romania
来源
LIFE-BASEL | 2024年 / 14卷 / 08期
关键词
aortic stenosis; aortic valve replacement; von Willebrand factor; hemostasis; surgical aortic valve replacement; transcatheter aortic valve replacement; ABO BLOOD-GROUP; DISEASE; ASSOCIATION;
D O I
10.3390/life14080934
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Aortic stenosis (AS) is a prevalent valvular disorder that poses a significant burden on healthcare systems due to its debilitating symptoms and high mortality rates if left untreated. Surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) are the primary interventions for severe AS, but perioperative complications such as bleeding remain a concern. Von Willebrand factor (VWF), a crucial player in hemostasis, is known to be altered in AS and may contribute to the hemostatic imbalance observed in these patients. This prospective study aimed to investigate the association between prosthetic valve type, size, and postprocedural VWF levels in patients undergoing aortic valve replacement (AVR) for severe AS. This study involved 39 consecutive patients diagnosed with severe AS who underwent SAVR or TAVR. By elucidating the VWF dynamics associated with different prosthetic valves, this study sought to provide valuable insights into personalized valve selection and perioperative management strategies.
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页数:12
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