Von Willebrand Factor Dynamics in Patients with Aortic Stenosis Undergoing Surgical and Transcatheter Valve Replacement

被引:0
|
作者
Grigorescu, Andrei Emanuel [1 ,2 ,3 ,4 ]
Anghel, Andrei [5 ]
Koch, Claudia [5 ]
Horhat, Florin George [6 ,7 ]
Savescu, Delia [8 ]
Feier, Horea [1 ,2 ,3 ]
机构
[1] Victor Babes Univ Med & Pharm Timisoara, Dept Cardiol, Timisoara 300041, Romania
[2] Inst Cardiovasc & Heart Dis Timisoara, Res Ctr, Timisoara 300310, Romania
[3] Inst Cardiovasc Dis, Div Cardiovasc Surg, Timisoara 300391, Romania
[4] Victor Babes Univ Med & Pharm Timisoara, Doctoral Sch Med Pharm, Timisoara 300041, Romania
[5] Victor Babes Univ Med & Pharm Timisoara, Dept Biochem, Timisoara 300041, Romania
[6] Victor Babes Univ Med & Pharm Timisoara, Ctr Translat Res & Syst Med, Timisoara 300041, Romania
[7] Victor Babes Univ Med & Pharm, Multidisciplinary Res Ctr Antimicrobial Resistance, Dept Microbiol, Timisoara 300041, Romania
[8] Childrens Emergency Hosp Louis Turcanu, Dept Lab, Timisoara, Romania
来源
LIFE-BASEL | 2024年 / 14卷 / 08期
关键词
aortic stenosis; aortic valve replacement; von Willebrand factor; hemostasis; surgical aortic valve replacement; transcatheter aortic valve replacement; ABO BLOOD-GROUP; DISEASE; ASSOCIATION;
D O I
10.3390/life14080934
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Aortic stenosis (AS) is a prevalent valvular disorder that poses a significant burden on healthcare systems due to its debilitating symptoms and high mortality rates if left untreated. Surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) are the primary interventions for severe AS, but perioperative complications such as bleeding remain a concern. Von Willebrand factor (VWF), a crucial player in hemostasis, is known to be altered in AS and may contribute to the hemostatic imbalance observed in these patients. This prospective study aimed to investigate the association between prosthetic valve type, size, and postprocedural VWF levels in patients undergoing aortic valve replacement (AVR) for severe AS. This study involved 39 consecutive patients diagnosed with severe AS who underwent SAVR or TAVR. By elucidating the VWF dynamics associated with different prosthetic valves, this study sought to provide valuable insights into personalized valve selection and perioperative management strategies.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] Treatment of Acquired von Willebrand Syndrome in Aortic Stenosis With Transcatheter Aortic Valve Replacement
    Spangenberg, Tobias
    Budde, Ulrich
    Schewel, Dimitry
    Frerker, Christian
    Thielsen, Thomas
    Kuck, Karl-Heinz
    Schaefer, Ulrich
    JACC-CARDIOVASCULAR INTERVENTIONS, 2015, 8 (05) : 692 - 700
  • [2] Von Willebrand factor and the aortic valve: Concepts that are important in the transcatheter aortic valve replacement era
    Ibrahim, Homam
    Rondina, Matthew T.
    Kleiman, Neal S.
    THROMBOSIS RESEARCH, 2018, 170 : 20 - 27
  • [3] Outcome of Patients with Low -Gradient Aortic Stenosis Undergoing Transcatheter or Surgical Aortic Valve Replacement
    Kugelman, Netta
    Jaffe, Ronen
    Aronson, Doron
    Sharoni, Erez
    Adawi, Salim
    Khader, Nader
    Shiran, Avinoam
    CARDIOVASCULAR REVASCULARIZATION MEDICINE, 2020, 21 (03) : 257 - 262
  • [4] Severe Aortic Valve Stenosis: Sustained Cure of Acquired von Willebrand Syndrome After Surgical Valve Replacement
    Frank, Rolf Dario
    Lanzmich, Regina
    Haager, Philipp K.
    Budde, Ulrich
    CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2017, 23 (03) : 229 - 234
  • [5] Impact of transcatheter aortic valve implantation on circulating von Willebrand factor in patients with severe aortic stenosis
    Varghese, Sonu S. S.
    Hetu, Marie-France
    Bowman, Mackenzie
    Herr, Julia
    Al-Turki, Mohamed
    Jaff, Zardasht
    James, Paula
    Malik, Paul
    Payne, Darrin
    Johri, Amer M. M.
    HAEMOPHILIA, 2023, 29 (05) : 1306 - 1312
  • [6] The impact of mitral stenosis on outcomes of aortic valve stenosis patient undergoing surgical aortic valve replacement or transcatheter aortic valve replacement
    Al-khadra, Yasser
    Darmoch, Fahed
    Baibars, Motaz
    Kaki, Amir
    Fanari, Zaher
    Alraies, M. Chadi
    JOURNAL OF INTERVENTIONAL CARDIOLOGY, 2018, 31 (05) : 655 - 660
  • [7] Transcatheter and surgical aortic valve replacement in patients with bicuspid aortic valve
    Husso, Annastiina
    Airaksinen, Juhani
    Juvonen, Tatu
    Laine, Mika
    Dahlbacka, Sebastian
    Virtanen, Marko
    Niemela, Matti
    Makikallio, Timo
    Savontaus, Mikko
    Eskola, Markku
    Raivio, Peter
    Valtola, Antti
    Biancari, Fausto
    CLINICAL RESEARCH IN CARDIOLOGY, 2021, 110 (03) : 429 - 439
  • [8] The Positive Impact of Early Frailty Levels on Mortality in Elderly Patients with Severe Aortic Stenosis Undergoing Transcatheter/Surgical Aortic Valve Replacement
    Mazzone, Annamaria
    Del Turco, Serena
    Trianni, Giuseppe
    Quadrelli, Paola
    Marotta, Marco
    Bastiani, Luca
    Gasbarri, Tommaso
    D'Agostino, Andreina
    Mariani, Massimiliano
    Basta, Giuseppina
    Foffa, Ilenia
    Sbrana, Silverio
    Vassalle, Cristina
    Ravani, Marcello
    Solinas, Marco
    Berti, Sergio
    JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE, 2023, 10 (05)
  • [9] Hemodynamics and Prognostic Impact of Concomitant Mitral Stenosis in Patients Undergoing Surgical or Transcatheter Aortic Valve Replacement for Aortic Stenosis
    Kato, Nahoko
    Padang, Ratnasari
    Pislaru, Cristina
    Miranda, William R.
    Hoshina, Mizuho
    Shibayama, Kentaro
    Watanabe, Hiroyuki
    Scott, Christopher G.
    Greason, Kevin L.
    Pislaru, Sorin, V
    Nkomo, Vuyisile T.
    Pellikka, Patricia A.
    CIRCULATION, 2019, 140 (15) : 1251 - 1260
  • [10] The use of transcatheter aortic valve replacement vs surgical aortic valve replacement for the treatment of aortic stenosis
    Jensen, Hanna A.
    Tsai, Lillian L.
    Thourani, Vinod H.
    RESEARCH REPORTS IN CLINICAL CARDIOLOGY, 2015, 6 : 105 - 116