Invasive fungal infections are rare in pediatric and young adult autologous hematopoietic stem cell transplant patients

被引:0
作者
Koo, Jane [1 ,2 ]
Huber, John [1 ,2 ]
Badia, Priscila [1 ,2 ]
Dunseath, Chloe [1 ,2 ]
O'Connor, Gabby [1 ,2 ]
Davies, Stella M. [1 ,2 ]
Dandoy, Christopher E. [1 ,2 ]
机构
[1] Cincinnati Childrens Hosp Med Ctr, Div Bone Marrow Transplantat & Immune Deficiency, Cincinnati, OH USA
[2] Univ Cincinnati, Dept Pediat, Cincinnati, OH USA
关键词
autologous stem cell transplant; fungal infections; invasive fungal infections; pediatric hematopoietic stem cell transplant; PREVENTION; MANAGEMENT; CHILDREN;
D O I
10.1002/pbc.31336
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background:<bold> </bold>Pediatric and young adult patients undergoing autologous hematopoietic stem cell transplant (auto-HSCT) face a crucial, yet understudied, risk of invasive fungal infections (IFI), especially compared to allogeneic transplants. This gap underscores the need for research in pediatric patients undergoing auto-HSCT. Our objective was to evaluate the incidence of IFI in pediatric and young adult patients during the first year after auto-HSCT. Materials and methods:<bold> </bold>We conducted a single-center retrospective analysis of 150 pediatric and young adult auto-HSCT patients who underwent transplant from January 2013 to January 2023. We focused on IFI incidence within the first-year post transplant, using the European Organization for Research and Treatment of Cancer/Mycoses Study Group (EORTC/MSG) criteria for IFI identification. Results:<bold> </bold>Among the 150 patients analyzed, with 240 unique transplant episodes, the primary indication was neuroblastoma (37.3%), and micafungin was extensively used for prophylaxis (82.7%). There was an absence of IFI from yeast and mold species, suggesting a low IFI risk in this cohort. The incidence of IFI in pediatric auto-HSCT recipients receiving micafungin primary antifungal prophylaxis is rare. Conclusions:<bold> </bold>The findings advocate for further research to refine prophylaxis guidelines and highlight the need for individualized risk assessment to optimize post-transplant care.
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页数:4
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