The effect of caffeine supplementation on muscular strength and endurance: A meta-analysis of meta-analyses

Background: Caffeine is commonly used as an ergogenic aid to increase strength and endurance in athletes. The results of meta-analyses in this regard are still conflicting. Therefore, the current umbrella meta -analysis was conducted to determine the effects of caffeine supplementation on muscle strength and endurance as a clear and final conclusion. Methods: Relevant studies were searched in international databases including PubMed, Scopus, and Web of Science until August 15, 2022. Meta-analysis studies examining the effects of caffeine supplementation on muscle strength and endurance were included in this study. Random effects model was used to perform meta-analysis. Additional analyses including subgroup and sensitivity analyzes were performed. Findings: In general, 9 meta-analyses were included in the study. The results showed that caffeine supplementation led to a significant increase in muscle strength (SMD = 0.18, 95 % CI: 0.14, 0.21; p < 0.001) and muscle endurance (SMD = 0.30, 95 % CI 0.21, 0.38; p < 0.001). Conclusion: Meta -analysis showed the significant effects of caffeine consumption on muscle strength and muscle endurance. Due to the lack of evidence, further studies are needed in the women's population.