Interplay of early negative life events, development of orbitofrontal cortical thickness and depression in young adulthood

被引：3

作者：

Backhausen, Lea L. ^{[1
,2
,3
]}

Granzow, Jonas ^{[2
,3
]}

Froehner, Juliane H. ^{[1
]}

Artiges, Eric ^{[4
,5
]}

Paillere-Martinot, Marie-Laure ^{[4
,6
]}

Lemaitre, Herve ^{[7
]}

Sticca, Fabio ^{[8
]}

Banaschewski, Tobias ^{[9
]}

Desrivieres, Sylvane ^{[10
]}

Grigis, Antoine ^{[7
]}

Heinz, Andreas ^{[11
,12
,13
,14
]}

Bruehl, Ruediger ^{[15
]}

Papadopoulos-Orfanos, Dimitri ^{[7
]}

Poustka, Luise ^{[16
]}

Hohmann, Sarah ^{[9
,17
]}

Robinson, Lauren ^{[18
]}

Walter, Henrik ^{[11
,12
,13
,14
]}

Winterer, Jeanne ^{[11
,12
,13
,14
,19
]}

Schumann, Gunter ^{[10
,20
,21
,22
]}

Martinot, Jean-Luc ^{[4
]}

Smolka, Michael N. ^{[1
]}

Vetter, Nora C. ^{[1
,2
,3
,23
]}

机构：

[1] TUD Dresden Univ Technol, Dept Psychiat & Psychotherapy, Dresden, Germany

[2] TUD Dresden Univ Technol, Dept Child & Adolescent Psychiat, Med Fac, Dresden, Germany

[3] TUD Dresden Univ Technol, Univ Hosp Carl Gustav Carus, Fetscherstr 74, D-01307 Dresden, Germany

[4] Univ Paris Saclay, Inst Natl Sante & Rech Medicale INSERM, CNRS, Ecole Normale Super Paris Saclay,U1299,Ctr Borelli, Gif Sur Yvette, France

[5] EPS Barthelemy Durand, Dept Psychiat, Lab D Psy, Etampes, France

[6] Hop La Pitie Salpetriere, Dept Child & Adolescent Psychiat, Paris, France

[7] Univ Paris Saclay, NeuroSpin, CEA, Gif Sur Yvette, France

[8] Univ Teacher Educ Special Needs, Inst Educ Support Behav Social Emot & Psychomotor, Zurich, Switzerland

[9] Heidelberg Univ, Cent Inst Mental Hlth, Med Fac Mannheim, Dept Child & Adolescent Psychiat & Psychotherapy, Mannheim, Germany

[10] Kings Coll London, Inst Psychiat Psychol & Neurosci, Ctr Populat Neurosci & Precis Med PONS, SGDP Ctr, London, England

[11] Charite Univ Med Berlin, Dept Psychiat & Neurosci, Berlin, Germany

[12] Free Univ Berlin, Berlin, Germany

[13] Humboldt Univ, Berlin, Germany

[14] Berlin Inst Hlth, Berlin, Germany

[15] Phys Tech Bundesanstalt PTB, Braunschweig & Berlin, Berlin, Germany

[16] Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Gottingen, Germany

[17] Univ Med Ctr Hamburg Eppendorf, Dept Child & Adolescent Psychiat Psychotherapy & P, Hamburg, Germany

[18] Kings Coll London, Dept Psychol Med, Sect Eating Disorders, Inst Psychiat Psychol & Neurosci, London, England

[19] Free Univ Berlin, Dept Educ & Psychol, Berlin, Germany

[20] Humboldt Univ, Dept Psychiat & Psychotherapy, PONS Res Grp, Campus Charite Mitte, Berlin, Germany

[21] Leibniz Inst Neurobiol, Magdeburg, Germany

[22] Fudan Univ, Inst Sci & Technol Brain inspired Intelligence IST, Shanghai, Peoples R China

[23] MSB Med Sch Berlin, Dept Psychol, Berlin, Germany

来源：

JCPP ADVANCES | 2024年 / 4卷 / 01期

基金：

美国国家卫生研究院; 欧盟地平线“2020”; 英国医学研究理事会;

关键词：

adolescence; depression; life events; longitudinal studies; structural MRI (sMRI); GREY-MATTER; VOLUME; MATURATION; ADVERSITY; STRESS; MALTREATMENT; METAANALYSIS; ADOLESCENCE; VALIDATION; CINGULATE;

D O I：

10.1002/jcv2.12210

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

BackgroundEarly negative life events (NLE) have long-lasting influences on neurodevelopment and psychopathology. Reduced orbitofrontal cortex (OFC) thickness was frequently associated with NLE and depressive symptoms. OFC thinning might mediate the effect of NLE on depressive symptoms, although few longitudinal studies exist. Using a complete longitudinal design with four time points, we examined whether NLE during childhood and early adolescence predict depressive symptoms in young adulthood through accelerated OFC thinning across adolescence.MethodsWe acquired structural MRI from 321 participants at two sites across four time points from ages 14 to 22. We measured NLE with the Life Events Questionnaire at the first time point and depressive symptoms with the Center for Epidemiologic Studies Depression Scale at the fourth time point. Modeling latent growth curves, we tested whether OFC thinning mediates the effect of NLE on depressive symptoms.ResultsA higher burden of NLE, a thicker OFC at the age of 14, and an accelerated OFC thinning across adolescence predicted young adults' depressive symptoms. We did not identify an effect of NLE on OFC thickness nor OFC thickness mediating effects of NLE on depressive symptoms.ConclusionsUsing a complete longitudinal design with four waves, we show that NLE in childhood and early adolescence predict depressive symptoms in the long term. Results indicate that an accelerated OFC thinning may precede depressive symptoms. Assessment of early additionally to acute NLEs and neurodevelopment may be warranted in clinical settings to identify risk factors for depression. Using a complete longitudinal design with four waves, we show that NLE in childhood and early adolescence predict depressive symptoms in the long term. Results indicate that an accelerated OFC thinning may precede depressive symptoms. Assessment of early additionally to acute NLEs and neurodevelopment may be warranted in clinical settings to identify risk factors for depression. image

引用

页数：12

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