Why non-human primates are needed in stroke preclinical research

被引：1

作者：

Long, Xiya ^{[1
,2
,3
]}

Zeng, Jinsheng ^{[1
,2
,3
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou, Peoples R China

[2] Guangdong Prov Key Lab Diag & Treatment Major Neur, Guangzhou, Peoples R China

[3] Natl Key Clin Dept, Key Discipline Neurol, Guangzhou, Peoples R China

来源：

STROKE AND VASCULAR NEUROLOGY | 2024年

关键词：

Non-human primates; stroke; ischaemic infarction; animal model; preclinical research; FOCAL CEREBRAL-ISCHEMIA; DOUBLE-BLIND; DL-3-N-BUTYLPHTHALIDE; MULTICENTER; DISEASE; MODELS; SLEEP;

D O I：

10.1136/svn-2024-003504

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Numerous seemingly promising cerebroprotectants previously validated in rodents almost all have failed in stroke clinical trials. The failure of clinical translation strikes an essential need to employ more ideal animal models in stroke research. Compared with the most commonly used rodent models of stroke, non-human primates (NHPs) are far more comparable to humans regarding brain anatomy, functionality and pathological features. The aim of this perspective was to summarise the advantages of NHPs stroke models over rodents, discuss the current limitations of NHPs models, and cast an outlook on the future development of NHPs in stroke preclinical research.

引用

页数：4

共 34 条

[1] β-amyloid aggregation in human brains with cerebrovascular lesions [J].

Aho, Leena ;

Jolkkonen, Jukka ;

Alafuzoff, Irina .

STROKE, 2006, 37 (12) :2940-2945

[2] Spatio-Temporal Characterization of Brain Inflammation in a Non-human Primate Stroke Model Mimicking Endovascular Thrombectomy [J].

Becker, Guillaume ;

Debatisse, Justine ;

Riviere, Margaux ;

Da Silva, Claire Crola ;

Beaudoin-Gobert, Maude ;

Eker, Omer ;

Wateau, Oceane ;

Cho, Tae Hee ;

Wiart, Marlene ;

Tremblay, Leon ;

Costes, Nicolas ;

Merida, Ines ;

Redoute, Jerome ;

Leon, Christelle ;

Langlois, Jean-Baptiste ;

Le Bars, Didier ;

Lancelot, Sophie ;

Nighoghossian, Norbert ;

Mechtouff, Laura ;

Canet-Soulas, Emmanuelle .

NEUROTHERAPEUTICS, 2023, 20 (03) :789-802

[3] Animal models of human mood [J].

Bliss-Moreau, Eliza ;

Rudebeck, Peter H. .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2021, 120 :574-582

[4] Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex [J].

Chen, Ao ;

Sun, Yidi ;

Lei, Ying ;

Li, Chao ;

Liao, Sha ;

Meng, Juan ;

Bai, Yiqin ;

Liu, Zhen ;

Liang, Zhifeng ;

Zhu, Zhiyong ;

Yuan, Nini ;

Yang, Hao ;

Wu, Zihan ;

Lin, Feng ;

Wang, Kexin ;

Li, Mei ;

Zhang, Shuzhen ;

Yang, Meisong ;

Fei, Tianyi ;

Zhuang, Zhenkun ;

Huang, Yiming ;

Zhang, Yong ;

Xu, Yuanfang ;

Cui, Luman ;

Zhang, Ruiyi ;

Han, Lei ;

Sun, Xing ;

Chen, Bichao ;

Li, Wenjiao ;

Huangfu, Baoqian ;

Ma, Kailong ;

Ma, Jianyun ;

Li, Zhao ;

Lin, Yikun ;

Wang, He ;

Zhong, Yanqing ;

Zhang, Huifang ;

Yu, Qian ;

Wang, Yaqian ;

Liu, Xing ;

Peng, Jian ;

Liu, Chuanyu ;

Chen, Wei ;

Pan, Wentao ;

An, Yingjie ;

Xia, Shihui ;

Lu, Yanbing ;

Wang, Mingli ;

Song, Xinxiang ;

Liu, Shuai .

CELL, 2023, 186 (17) :3726-+

[5] Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain [J].

Cook, Douglas J. ;

Teves, Lucy ;

Tymianski, Michael .

NATURE, 2012, 483 (7388) :213-U112

[6] PET-MRI nanoparticles imaging of blood-brain barrier damage and modulation after stroke reperfusion [J].

Debatisse, Justine ;

Eker, Omer Faruk ;

Wateau, Oceane ;

Cho, Tae-Hee ;

Wiart, Marlene ;

Ramonet, David ;

Costes, Nicolas ;

Merida, Ines ;

Leon, Christelle ;

Dia, Maya ;

Paillard, Melanie ;

Confais, Joachim ;

Rossetti, Fabien ;

Langlois, Jean-Baptiste ;

Troalen, Thomas ;

Iecker, Thibaut ;

Le Bars, Didier ;

Lancelot, Sophie ;

Bouchier, Baptiste ;

Lukasziewicz, Anne-Claire ;

Oudotte, Adrien ;

Nighoghossian, Norbert ;

Ovize, Michel ;

Contamin, Hugues ;

Lux, Francois ;

Tillement, Olivier ;

Canet-Soulas, Emmanuelle .

BRAIN COMMUNICATIONS, 2020, 2 (02)

[7] White matter tract anatomy in the rhesus monkey: a fiber dissection study [J].

Decramer, Thomas ;

Swinnen, Stijn ;

van Loon, Johannes ;

Janssen, Peter ;

Theys, Tom .

BRAIN STRUCTURE & FUNCTION, 2018, 223 (08) :3681-3688

[8] Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations [J].

Fisher, Marc ;

Feuerstein, Giora ;

Howells, David W. ;

Hurn, Patricia D. ;

Kent, Thomas A. ;

Savitz, Sean I. ;

Lo, Eng H. .

STROKE, 2009, 40 (06) :2244-2250

[9] Cell transcriptomic atlas of the non-human primate Macaca fascicularis [J].

Han, Lei ;

Wei, Xiaoyu ;

Liu, Chuanyu ;

Volpe, Giacomo ;

Zhuang, Zhenkun ;

Zou, Xuanxuan ;

Wang, Zhifeng ;

Pan, Taotao ;

Yuan, Yue ;

Zhang, Xiao ;

Fan, Peng ;

Guo, Pengcheng ;

Lai, Yiwei ;

Lei, Ying ;

Liu, Xingyuan ;

Yu, Feng ;

Shangguan, Shuncheng ;

Lai, Guangyao ;

Deng, Qiuting ;

Liu, Ya ;

Wu, Liang ;

Shi, Quan ;

Yu, Hao ;

Huang, Yunting ;

Cheng, Mengnan ;

Xu, Jiangshan ;

Liu, Yang ;

Wang, Mingyue ;

Wang, Chunqing ;

Zhang, Yuanhang ;

Xie, Duo ;

Yang, Yunzhi ;

Yu, Yeya ;

Zheng, Huiwen ;

Wei, Yanrong ;

Huang, Fubaoqian ;

Lei, Junjie ;

Huang, Waidong ;

Zhu, Zhiyong ;

Lu, Haorong ;

Wang, Bo ;

Wei, Xiaofeng ;

Chen, Fengzhen ;

Yang, Tao ;

Du, Wensi ;

Chen, Jing ;

Xu, Shibo ;

An, Juan ;

Ward, Carl ;

Wang, Zongren .

NATURE, 2022, 604 (7907) :723-+

[10] Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial [J].

Hill, Michael D. ;

Goyal, Mayank ;

Menon, Bijoy K. ;

Nogueira, Raul G. ;

McTaggart, Ryan A. ;

Demchuk, Andrew M. ;

Poppe, Alexandre Y. ;

Buck, Brian H. ;

Field, Thalia S. ;

Dowlatshahi, Dar ;

van Adel, Brian A. ;

Swartz, Richard H. ;

Shah, Ruchir A. ;

Sauvageau, Eric ;

Zerna, Charlotte ;

Ospel, Johanna M. ;

Joshi, Manish ;

Almekhlafi, Mohammed A. ;

Ryckborst, Karla J. ;

Lowerison, Mark W. ;

Heard, Kathy ;

Garman, David ;

Haussen, Diogo ;

Cutting, Shawna M. ;

Coutts, Shelagh B. ;

Roy, Daniel ;

Rempel, Jeremy L. ;

Rohr, Axel C. R. ;

Lancu, Daniela ;

Sahlas, Demetrios J. ;

Yu, Amy Y. X. ;

Devlin, Thomas G. ;

Hanel, Ricardo A. ;

Puetz, Volker ;

Silver, Frank L. ;

Campbell, Bruce C., V ;

Chapot, Rene ;

Teitelbaum, Jeanne ;

Mandzia, Jennifer L. ;

Kleinig, Timothy J. ;

Turkel-Parrella, David ;

Heck, Donald ;

Kelly, Michael E. ;

Bharatha, Aditya ;

Bang, Oh Young ;

Jadhav, Ashutosh ;

Gupta, Rishi ;

Frei, Donald F. ;

Tarpley, Jason W. ;

McDougall, Cameron G. .

LANCET, 2020, 395 (10227) :878-887

← 1 2 3 4 →