Nivolumab-Induced Diabetic Ketoacidosis: A Case Report

被引：0

作者：

Giese, Drake ^{[1
]}

Elkhedr, Ali ^{[2
]}

Jnaneswaran, Geethu ^{[2
]}

Ernste, Katherine M. ^{[3
]}

机构：

[1] Med Coll Wisconsin, Orthoped, Milwaukee, WI 53226 USA

[2] Marshfield Clin Fdn Med Res & Educ, Internal Med, Marshfield, WI USA

[3] Med Coll Wisconsin, Family Med, Milwaukee, WI USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2024年 / 16卷 / 07期

关键词：

immunomodulatory therapy; monoclonal antibody; autoimmune disease; diabetic ketoacidosis; checkpoint inhibitor; nivolumab;

D O I：

10.7759/cureus.64319

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nivolumab, an investigational monoclonal antibody targeting a specific immune pathway, has shown promise in treating various autoimmune diseases. However, like other immunomodulatory agents, it has potential side effects. This case report describes a rare adverse event of nivolumab-induced diabetic ketoacidosis (DKA) in a patient with a history of adrenal insufficiency secondary to nivolumab. The patient presented with symptoms of hyperglycemia, metabolic acidosis, and ketosis after receiving nivolumab therapy for 12 cycles. Prompt recognition and management of nivolumab-induced DKA are crucial to prevent complications and ensure patient safety.

引用

页数：4

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