Advances in Engineering Circular RNA Vaccines

被引:1
作者
Zhang, Zhongyan [1 ]
Fu, Yuanlei [2 ]
Ju, Xiaoli [2 ]
Zhang, Furong [2 ]
Zhang, Peng [1 ]
He, Meilin [2 ]
机构
[1] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
[2] Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264005, Peoples R China
来源
PATHOGENS | 2024年 / 13卷 / 08期
关键词
circular RNA vaccines; circularization; RNA therapeutics; mRNA; RNA delivery; SOLID TUMORS; INTRON; CELLS; SELF; TRANSLATION; INITIATION; INFECTION; EFFICACY; IMMUNITY; DELIVERY;
D O I
10.3390/pathogens13080692
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Engineered circular RNAs (circRNAs) are a class of single-stranded RNAs with head-to-tail covalently linked structures that integrate open reading frames (ORFs) and internal ribosome entry sites (IRESs) with the function of coding and expressing proteins. Compared to mRNA vaccines, circRNA vaccines offer a more improved method that is safe, stable, and simple to manufacture. With the rapid revelation of the biological functions of circRNA and the success of Severe Acute Respiratory Coronavirus Type II (SARS-CoV-2) mRNA vaccines, biopharmaceutical companies and researchers around the globe are attempting to develop more stable circRNA vaccines for illness prevention and treatment. Nevertheless, research on circRNA vaccines is still in its infancy, and more work and assessment are needed for their synthesis, delivery, and use. In this review, based on the current understanding of the molecular biological properties and immunotherapeutic mechanisms of circRNA, we summarize the current preparation methods of circRNA vaccines, including design, synthesis, purification, and identification. We discuss their delivery strategies and summarize the challenges facing the clinical application of circRNAs to provide references for circRNA vaccine-related research.
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页数:18
相关论文
共 128 条
[1]   Rolling Circle Translation of Circular RNA in Living Human Cells [J].
Abe, Naoko ;
Matsumoto, Ken ;
Nishihara, Mizuki ;
Nakano, Yukiko ;
Shibata, Aya ;
Maruyama, Hideto ;
Shuto, Satoshi ;
Matsuda, Akira ;
Yoshida, Minoru ;
Ito, Yoshihiro ;
Abe, Hiroshi .
SCIENTIFIC REPORTS, 2015, 5
[2]   Circular RNA vaccine induces potent T cell responses [J].
Amaya, Laura ;
Grigoryan, Lilit ;
Li, Zhijian ;
Lee, Audrey ;
Wender, Paul A. ;
Pulendran, Bali ;
Chang, Howard Y. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 120 (20)
[3]   Exosomes as bio-inspired nanocarriers for RNA delivery: preparation and applications [J].
Amiri, Ala ;
Bagherifar, Rafieh ;
Dezfouli, Ehsan Ansari ;
Kiaie, Seyed Hossein ;
Jafari, Reza ;
Ramezani, Reihaneh .
JOURNAL OF TRANSLATIONAL MEDICINE, 2022, 20 (01)
[4]   A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes [J].
Arevalo, Claudia P. ;
Bolton, Marcus J. ;
Le Sage, Valerie ;
Ye, Naiqing ;
Furey, Colleen ;
Muramatsu, Hiromi ;
Alameh, Mohamad-Gabriel ;
Pardi, Norbert ;
Drapeau, Elizabeth M. ;
Parkhouse, Kaela ;
Garretson, Tyler ;
Morris, Jeffrey S. ;
Moncla, Louise H. ;
Tam, Ying K. ;
Fan, Steven H. Y. ;
Lakdawala, Seema S. ;
Weissman, Drew ;
Hensley, Scott E. .
SCIENCE, 2022, 378 (6622) :899-904
[5]   Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].
Baden, Lindsey R. ;
El Sahly, Hana M. ;
Essink, Brandon ;
Kotloff, Karen ;
Frey, Sharon ;
Novak, Rick ;
Diemert, David ;
Spector, Stephen A. ;
Rouphael, Nadine ;
Creech, C. Buddy ;
McGettigan, John ;
Khetan, Shishir ;
Segall, Nathan ;
Solis, Joel ;
Brosz, Adam ;
Fierro, Carlos ;
Schwartz, Howard ;
Neuzil, Kathleen ;
Corey, Larry ;
Gilbert, Peter ;
Janes, Holly ;
Follmann, Dean ;
Marovich, Mary ;
Mascola, John ;
Polakowski, Laura ;
Ledgerwood, Julie ;
Graham, Barney S. ;
Bennett, Hamilton ;
Pajon, Rolando ;
Knightly, Conor ;
Leav, Brett ;
Deng, Weiping ;
Zhou, Honghong ;
Han, Shu ;
Ivarsson, Melanie ;
Miller, Jacqueline ;
Zaks, Tal .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416
[6]   Research progress on circular RNA vaccines [J].
Bai, Yu ;
Liu, Dong ;
He, Qian ;
Liu, Jianyang ;
Mao, Qunying ;
Liang, Zhenglun .
FRONTIERS IN IMMUNOLOGY, 2023, 13
[7]   Lipid Nanoparticle Formulations for Enhanced Co-delivery of siRNA and mRNA [J].
Ball, Rebecca L. ;
Hajj, Khalid A. ;
Vizelman, Jamie ;
Bajaj, Palak ;
Whitehead, Kathryn A. .
NANO LETTERS, 2018, 18 (06) :3814-3822
[8]   The clinical progress of mRNA vaccines and immunotherapies [J].
Barbier, Ann J. ;
Jiang, Allen Yujie ;
Zhang, Peng ;
Wooster, Richard ;
Anderson, Daniel G. .
NATURE BIOTECHNOLOGY, 2022, 40 (06) :840-854
[9]   Production and Purification of Artificial Circular RNA Sponges for Application in Molecular Biology and Medicine [J].
Breuer, Janina ;
Rossbach, Oliver .
METHODS AND PROTOCOLS, 2020, 3 (02) :1-14
[10]  
Carmona E.M., 2019, Circular RNA: Design Criteria for Optimal Therapeutical Utility