Inflammatory indexes and anemia in chronic kidney disease: correlation and survival analysis of the National Health and Nutrition Examination Survey 2005-2018

被引:2
作者
Fu, Shaojie [1 ]
Huang, Jingda [1 ]
Feng, Zhenbang [2 ]
Wang, Haitao [3 ]
Xu, Hongzhao [1 ]
Wu, Meiyan [1 ]
Ma, Fuzhe [1 ]
Xu, Zhonggao [1 ]
机构
[1] Jilin Univ, Hosp 1, Dept Nephrol, Changchun, Peoples R China
[2] Jilin Univ, Ctr Oncol, Hosp 1, Changchun, Peoples R China
[3] Jilin Univ, Dept Crit Care Med, Hosp 1, Changchun, Peoples R China
基金
中国国家自然科学基金;
关键词
Systemic immune-inflammation index; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; chronic kidney disease; anemia; NHANES; ALL-CAUSE MORTALITY; CARDIOVASCULAR EVENTS; IFN-GAMMA; ERYTHROPOIETIN; CELLS; INHIBITION; PROGNOSIS; RATIO; RISK;
D O I
10.1080/0886022X.2024.2399314
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
BackgroundThere is currently no research on the correlation between novel inflammatory indexes systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the risk of anemia in chronic kidney disease (CKD) population, as well as survival analysis in CKD with anemia. MethodsThis investigation encompassed 4444 adult subjects out of the National Health and Nutrition Examination Survey (NHANES) between 2005 and 2018. The study utilized multi-variable logistic regression to assess the relationship between SII, NLR, PLR, and anemia risk occurrence in CKD population. Survival differences in CKD patients with anemia, based on varying levels of SII, NLR, and PLR were evaluated employing Kaplan-Meier and Cox proportional hazards models. ResultsThe adjusted logistic regression model demonstrates that SII, NLR, and PLR are associated with the risk of anemia occurrence in CKD population. Kaplan-Meier's analysis reveals significant differences in survival rates among CKD patients with anemia stratified by NLR levels. The adjusted Cox proportional hazards model shows that the higher NLR group has a 30% elevated risk of all-cause mortality contrasted with lower group (hazard ratio, HR: 1.30, confidence interval (CI) [1.01, 1.66], p value <.04). Restricted cubic spline (RCS) demonstrates no nonlinear relationship between NLR and all-cause mortality. Lastly, sub-cohort analysis indicates that in populations with diabetes, hypertension, and hyperuricemia, NLR levels have a greater impact on all-cause mortality. ConclusionsControlling inflammation may reduce the occurrence of anemia in CKD populations, with NLR serving to be a potential prognostic indicator for survival results within CKD patients suffering from co-morbid anemia.
引用
收藏
页数:11
相关论文
共 57 条
[51]  
WHO, 2024, ABOUT US
[52]   Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies [J].
Xu, Suowen ;
Ilyas, Iqra ;
Little, Peter J. ;
Li, Hong ;
Kamato, Danielle ;
Zheng, Xueying ;
Luo, Sihui ;
Li, Zhuoming ;
Liu, Peiqing ;
Han, Jihong ;
Harding, Ian C. ;
Ebong, Eno E. ;
Cameron, Scott J. ;
Stewart, Alastair G. ;
Weng, Jianping .
PHARMACOLOGICAL REVIEWS, 2021, 73 (03) :924-967
[53]   Poor recognition and undertreatment of anemia in patients with chronic kidney disease managed in primary care [J].
Xu, Yang ;
Evans, Marie ;
Mazhar, Faizan ;
Arnlov, Johan ;
Cockburn, Elinor ;
Barany, Peter ;
Carrero, Juan-Jesus .
JOURNAL OF INTERNAL MEDICINE, 2023, 294 (05) :628-639
[54]   Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) [J].
Yuan, Qiongjing ;
Wang, Jinwei ;
Peng, Zhangzhe ;
Zhou, Qiaoling ;
Xiao, Xiangcheng ;
Xie, Yanyun ;
Wang, Wei ;
Huang, Ling ;
Tang, Wenbin ;
Sun, Danni ;
Zhang, Luxia ;
Wang, Fang ;
Zhao, Ming-Hui ;
Tao, Lijian ;
He, Kevin ;
Xu, Hui .
JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 17 (1)
[55]  
Zahorec R, 2001, Bratisl Lek Listy, V102, P5
[56]   A comprehensive analysis of the association between anemia and systemic inflammation in older patients with cancer [J].
Zhang, Xi ;
Huang, Jia-Xin ;
Tang, Meng ;
Zhang, Qi ;
Deng, Li ;
Song, Chun-Hua ;
Li, Wei ;
Yang, Min ;
Shi, Han-Ping ;
Cong, Ming-Hua .
SUPPORTIVE CARE IN CANCER, 2024, 32 (01)
[57]   Neutrophil-to-lymphocyte ratio in relation to the risk of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a systematic review and meta-analysis [J].
Zhao, Wen-Man ;
Tao, Shu-Man ;
Liu, Gui-Ling .
RENAL FAILURE, 2020, 42 (01) :1059-1066