White matter damage and degeneration in traumatic brain injury

被引：6

作者：

Armstrong, Regina C. ^{[1
,2
]}

Sullivan, Genevieve M. ^{[1
,2
,3
]}

Perl, Daniel P. ^{[4
,5
]}

Rosarda, Jessica D. ^{[1
]}

Radomski, Kryslaine L. ^{[1
]}

机构：

[1] Uniformed Serv Univ Hlth Sci, Anat Physiol & Genet, Bethesda, MD 20814 USA

[2] Mil Traumat Brain Injury Initiat, Bethesda, MD 20814 USA

[3] Henry M Jackson Fdn Adv Mil Med, Bethesda, MD USA

[4] Uniformed Serv Univ Hlth Sci, Sch Med, Pathol, Bethesda, MD USA

[5] Uniformed Serv Univ Brain Tissue Repository, Dept Def, Bethesda, MD USA

来源：

TRENDS IN NEUROSCIENCES | 2024年 / 47卷 / 09期

关键词：

UNFOLDED PROTEIN RESPONSE; DIFFUSE AXONAL INJURY; MYELIN; MECHANISMS; OLIGODENDROCYTES; TENSOR; DYSFUNCTION; PATHOLOGY; ATROPHY; SINGLE;

D O I：

10.1016/j.tins.2024.07.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often leads to persistent symptoms, and the risk of poor patient outcomes increases with aging. TBI damages neurons and long axons within white matter tracts that are critical for communication between brain regions; this causes slowed information processing and neuronal circuit dysfunction. This review focuses on white matter injury after TBI and the multifactorial processes that underlie white matter damage, potential for recovery, and progression of degeneration. A multiscale perspective across clinical and preclinical advances is presented to encourage interdisciplinary insights from whole-brain neuroimaging of white matter tracts down to cellular and molecular responses of axons, myelin, and glial cells within white matter tissue.

引用

页码：677 / 692

页数：16

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