Clinical Management of Postoperative Growth Hormone Deficiency in Hypothalamic-Pituitary Tumors

被引:2
作者
Iglesias, Pedro [1 ,2 ]
机构
[1] Hosp Univ Puerta Hierro, Dept Endocrinol & Nutr, Majadahonda 28222, Madrid, Spain
[2] Inst Invest Sanitaria Puerta Hierro Segovia Arana, Majadahonda 28222, Madrid, Spain
关键词
growth hormone; pituitary tumor; postoperative management; QUALITY-OF-LIFE; INSULIN-INDUCED HYPOGLYCEMIA; GH REPLACEMENT THERAPY; INTIMA-MEDIA THICKNESS; CARDIOVASCULAR RISK; ADULT PATIENTS; HYPOPITUITARY PATIENTS; BODY-COMPOSITION; RECURRENCE; DIAGNOSIS;
D O I
10.3390/jcm13154307
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The present review focuses on growth hormone (GH) deficiency in pediatric and adult patients following surgery for hypothalamic-pituitary tumors, with a special emphasis on hormone replacement therapy with recombinant human growth hormone (rhGH). The symptoms and metabolic changes associated with GH deficiency are reviewed, and the potential risks and therapeutic outcomes of rhGH treatment in these patients are discussed. This review emphasizes the importance of rhGH in the normalization of growth in children and the improvement of quality of life (QoL) and metabolic health in adults. Aspects related to efficacy, safety, dosage, duration of treatment, and QoL in this population are analyzed. The need for regular follow-up and dose adjustment to maintain the optimal IGF-I levels in these patients is emphasized, as is the importance of individualized assessment and collaboration with a specialized multidisciplinary medical team to make the appropriate therapeutic decisions. Furthermore, continuous follow-up are necessary to optimize the clinical outcomes in this patient population.
引用
收藏
页数:15
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