Effect of Polysaccharides Isolated from Saussurea salicifolia (L.) DC on Th2-Dependent Immune Response

被引：0
|
作者：
Ligacheva, A. A. [1 ]
Danilets, M. G. [1 ]
Gulina, E. I. [2 ]
Selivanova, N. S. [1 ,2 ]
Trofimova, E. S. [1 ,2 ]
Sherstoboev, E. Yu. [2 ]
Avdeeva, E. Yu. [2 ]
Reshetov, Ya. E. [2 ]
Krivoshchekov, S. V. [2 ]
Zhdanov, V. V. [1 ]
Belousov, M. V. [2 ]
机构：
[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia
[2] Siberian State Med Univ, Minist Hlth Russian Federat, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2024年 / 177卷 / 04期
关键词：
water-soluble polysaccharides; Saussurea salicifolia (L.) DC; anaphylaxis; IgG1 and IgE; mast cell degranulation;
D O I：
10.1007/s10517-024-06210-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effect of polysaccharides isolated from the aboveground parts of Saussurea salicifolia (L.) DC on Th2 type immune response reactions was studied. Administration of water-soluble polysaccharides presented by arabino-galacturonans (weight average molecular weight 158.49 kDa) to mice against the background of experimental Th2 immunity reduced the severity of anaphylactic and local immediate type hypersensitivity reactions. It also suppressed the production of ovalbumin-specific IgE and IgG1 and increased the stability of mast cell membranes. The studied polysaccharide complex increased IFN gamma secretion and inhibited IL-4 synthesis. These findings suggest that these polysaccharides may be considered as potential anti-allergic agents that suppress the development of allergy in its early stages.
引用
收藏
页码：470 / 475
页数：6
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