Spectrum of Non-Obstructive Coronary Artery Disease and Its Relationship with Atrial Fibrillation

被引：3

作者：

Oancea, Alexandru-Florinel ^{[1
,2
]}

Morariu, Paula Cristina ^{[1
,2
]}

Buburuz, Ana Maria ^{[1
,2
]}

Miftode, Ionela-Larisa ^{[3
,4
]}

Miftode, Radu Stefan ^{[1
,2
]}

Mitu, Ovidiu ^{[1
,2
]}

Jigoranu, Alexandru ^{[1
,2
]}

Floria, Diana-Elena ^{[1
,2
]}

Timpau, Amalia ^{[1
,2
]}

Vata, Andrei ^{[3
,4
]}

Plesca, Claudia ^{[3
,4
]}

Botnariu, Gina ^{[2
,5
]}

Burlacu, Alexandru ^{[1
,6
]}

Scripcariu, Dragos-Viorel ^{[1
,7
]}

Raluca, Mitea ^{[8
]}

Cuciureanu, Magdalena ^{[9
]}

Tanase, Daniela Maria ^{[1
,2
]}

Costache-Enache, Irina Iuliana ^{[1
,2
]}

Floria, Mariana ^{[1
,2
]}

机构：

[1] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Internal Med 1, Iasi 700115, Romania

[2] St Spiridon Emergency Hosp, Iasi 700115, Romania

[3] Grigore T Popa Univ Med & Pharm, Fac Med, Dept Internal Med 2, Iasi 700115, Romania

[4] St Parascheva Clin Hosp Infect Dis, Iasi 700116, Romania

[5] Grigore T Popa Univ Med & Pharm, Unit Diabet Nutr & Metab Dis, Iasi 700115, Romania

[6] Cardiovasc Dis Inst, Iasi 700503, Romania

[7] Reg Inst Oncol, Iasi 700483, Romania

[8] Univ Lucian Blaga, Fac Med Victor Papilian, Sibiu 550169, Romania

[9] Grigore T Popa Univ Med & Pharm, Dept Pharmacol, Iasi 700115, Romania

来源：

JOURNAL OF CLINICAL MEDICINE | 2024年 / 13卷 / 16期

关键词：

coronary ischemia; non-obstructive coronary artery disease; INOCA; MINOCA; ANOCA; atrial fibrillation; begets; FLOW RESERVE; MICROVASCULAR DYSFUNCTION; ENDOTHELIAL DYSFUNCTION; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; BLOOD-FLOW; PATHOPHYSIOLOGY; RESISTANCE; ISCHEMIA; THERMODILUTION;

D O I：

10.3390/jcm13164921

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article aims to analyze the relationship between non-obstructive coronary artery disease (NOCAD) and atrial fibrillation (AF), exploring the underlying pathophysiological mechanisms and implications for clinical management. NOCAD and AF are prevalent cardiovascular conditions that often coexist, yet their interrelation is not well understood. NOCAD can lead to ischemic necrosis of cardiomyocytes and their replacement with fibrous tissue, sustaining focal ectopic activity in atrial myocardium. Atrial fibrillation, on the other hand, the most common sustained cardiac arrhythmia, is able to accelerate atherosclerosis and increase oxygen consumption in the myocardium, creating a mismatch between supply and demand, and thus promoting the development or worsening of coronary ischemia. Therefore, NOCAD and AF seem to be a complex interplay with one begets another.

引用

页数：21

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