Exploring the Potential Long-term Impact of SARS-CoV-2 on Protein Misfolding and Amyloid-related Conditions

被引：0
作者：
Rashid, Md Harun [1 ]
Singha, Srinjana [1 ]
Arshad, Faheem [2 ]
Sen, Priyankar [1 ]
机构：
[1] VIT Univ, Vellore Inst Technol, Ctr Bio Separat Technol CBST, Technol Tower, Vellore 632014, Tamil Nadu, India
[2] Natl Inst Mental Hlth & Neurosci NIMHANS, Dept Neurol, Bengaluru, Karnataka, India
来源：
PROTEIN AND PEPTIDE LETTERS | 2024年 / 31卷 / 08期
关键词：
COVID-19; amyloidosis; amyloid beta; SARS-CoV-2; spike protein; protein misfolding; AA AMYLOIDOSIS; COVID-19; VACCINATION; COMPLICATIONS; INFECTION; RECEPTOR; RISK;
D O I：
10.2174/0109298665333817240821111641
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The long-term impact of the COVID-19 pandemic concerns risk to human health, particularly its potential association with protein misfolding and amyloidosis. This review article explores the causality relationship between SARS-CoV-2 infection, and protein misfolding, leading to amyloid-related conditions. It delves into the mechanisms by which viral proteins may accelerate amyloid formation, exacerbating post-infection complications, including neurological sequelae. Drawing from interdisciplinary research and clinical observations, the potential links between COVID-19, vaccination, and amyloidosis, emphasize the importance of understanding the long-term effect of post-COVID symptoms. This review examines the potential role of COVID-19-related proteins in the formation of amyloid in other related proteins of amyloidosis.
引用
收藏
页码：602 / 610
页数：9
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