Low-grade follicular lymphoma with interferon regulatory factor-4 rearrangement: Expanding the spectrum of interferon regulatory factor-4-rearranged lymphomas

被引：0
|
作者：
Sakhdari, Ali [1 ]
Sabatini, Peter J. B. [1 ]
Geevar, Tulasi [1 ]
Zhang, Tong [1 ]
Delabie, Jan M. A. [1 ]
机构：
[1] Univ Hlth Network, Dept Lab Med & Pathobiol, Lab Med & Pathobiol, Toronto, ON, Canada
来源：
EJHAEM | 2024年 / 5卷 / 05期
关键词：
IRF4; rearrangement; mutational profile; small B-cell lymphoma; B-CELL LYMPHOMA; TRANSLOCATIONS; DIAGNOSIS; SUBTYPE;
D O I：
10.1002/jha2.992
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent years, the recognition of distinct lymphoma entities has expanded with advancements in molecular characterization. Large B-cell Lymphoma with interferon regulatory factor-4 (IRF4) rearrangement (LBCL-IRF4-R) is one such entity. We present a case of classic low-grade follicular lymphoma with IRF4 rearrangement in a 50-year-old male, demonstrating an unusual immunophenotypic and genetic profile reminiscent of LBCL-IRF4-R. Molecular analysis revealed mutations in CREBBP, KMT2D, IRF4, and CARD11, with previously unreported variants identified in IRF4 and CREBBP. This case broadens the spectrum of B-cell lymphomas associated with IRF4 rearrangement by demonstrating a small B-cell lymphoma with this genetic feature.
引用
收藏
页码：1068 / 1071
页数：4
相关论文
共 50 条
  • [41] Hypothermia Protects Mice Against Ischemic Stroke by Modulating Macrophage Polarization Through Upregulation of Interferon Regulatory Factor-4
    Yu, Xinyuan
    Feng, Yanping
    Liu, Renzhong
    Chen, Qianxue
    JOURNAL OF INFLAMMATION RESEARCH, 2021, 14 : 1271 - 1281
  • [42] Expression of interferon regulatory factor 4 in chronic myeloid leukemia:: Correlation with response to interferon alfa therapy
    Schmidt, M
    Hochhaus, A
    König-Merediz, SA
    Brendel, C
    Proba, J
    Hoppe, GJ
    Wittig, B
    Ehninger, G
    Hehlmann, R
    Neubauer, A
    JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (19) : 3331 - 3338
  • [43] Copy Number Abnormalities Of The Interferon Regulatory Factor-4 (IRF4) Gene Are Associated With IRF4/MUM1 Expression In Peripheral T-Cell Lymphomas
    Boddicker, Rebecca L.
    Knudson, Ryan A.
    Ketterling, Rhett P.
    Mark, Law E.
    Xing, Xiaoming
    Cerhan, James R.
    Wu, Yanhong
    Cunningham, Julie M.
    Ansell, Stephen M.
    Feldman, Andrew L.
    BLOOD, 2013, 122 (21)
  • [44] Expression of interferon regulatory factor 4 and inflammation in secondary injury of intracerebral haemorrhage
    Wang, Bingqian
    Li, Xiaopeng
    Dong, Tianyu
    Gao, Feng
    Li, Zhenzhong
    Ma, Zenglu
    FOLIA NEUROPATHOLOGICA, 2021, 59 (03) : 291 - 297
  • [45] Folding and purification of a recombinantly expressed interferon regulatory factor, IRF-4
    Moellering, BJ
    Yoshinaga, SK
    Hui, A
    Delaney, JM
    Hara, S
    Narhi, LO
    Westcott, KR
    PROTEIN EXPRESSION AND PURIFICATION, 1999, 16 (01) : 160 - 170
  • [46] Interferon regulatory factor 4 a master regulator of hypertensive kidney fibrosis and inflammation?
    Kyaw, Tin
    Drummond, Grant
    Bobik, Alex
    JOURNAL OF HYPERTENSION, 2023, 41 (06) : 906 - 908
  • [47] Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4
    Lohoff, M
    Mittrücker, HW
    Prechtl, S
    Bischof, S
    Sommer, F
    Kock, S
    Ferrick, DA
    Duncan, GS
    Gessner, A
    Mak, TW
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) : 11808 - 11812
  • [48] Essential role of interferon regulatory factor 4 (IRF4) in immune cell development
    Nam, Sorim
    Lim, Jong-Seok
    ARCHIVES OF PHARMACAL RESEARCH, 2016, 39 (11) : 1548 - 1555
  • [49] Essential role of interferon regulatory factor 4 (IRF4) in immune cell development
    Sorim Nam
    Jong-Seok Lim
    Archives of Pharmacal Research, 2016, 39 : 1548 - 1555
  • [50] Functional Roles of Interferon Regulatory Factor4 (IRF4) in Adipocyte Biology
    Eguchi, Jun
    Wang, Xun
    Rosen, Evan D.
    DIABETES, 2009, 58 : A94 - A94
12345