Low-grade follicular lymphoma with interferon regulatory factor-4 rearrangement: Expanding the spectrum of interferon regulatory factor-4-rearranged lymphomas

被引：0
|
作者：
Sakhdari, Ali [1 ]
Sabatini, Peter J. B. [1 ]
Geevar, Tulasi [1 ]
Zhang, Tong [1 ]
Delabie, Jan M. A. [1 ]
机构：
[1] Univ Hlth Network, Dept Lab Med & Pathobiol, Lab Med & Pathobiol, Toronto, ON, Canada
来源：
EJHAEM | 2024年 / 5卷 / 05期
关键词：
IRF4; rearrangement; mutational profile; small B-cell lymphoma; B-CELL LYMPHOMA; TRANSLOCATIONS; DIAGNOSIS; SUBTYPE;
D O I：
10.1002/jha2.992
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In recent years, the recognition of distinct lymphoma entities has expanded with advancements in molecular characterization. Large B-cell Lymphoma with interferon regulatory factor-4 (IRF4) rearrangement (LBCL-IRF4-R) is one such entity. We present a case of classic low-grade follicular lymphoma with IRF4 rearrangement in a 50-year-old male, demonstrating an unusual immunophenotypic and genetic profile reminiscent of LBCL-IRF4-R. Molecular analysis revealed mutations in CREBBP, KMT2D, IRF4, and CARD11, with previously unreported variants identified in IRF4 and CREBBP. This case broadens the spectrum of B-cell lymphomas associated with IRF4 rearrangement by demonstrating a small B-cell lymphoma with this genetic feature.
引用
收藏
页码：1068 / 1071
页数：4
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