Benznidazole levels in blood vary with age in rats

被引：6

作者：

Fernanda Bulffer, Romina ^{[1
]}

Alberto Castro, Jose ^{[1
]}

Laura Fanelli, Silvia ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Ctr Invest Toxicol, Inst Sci & Technol Res Armed Forces, Buenos Aires, DF, Argentina

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 2011年 / 106卷 / 03期

关键词：

benznidazole; rat blood; HPLC; Chagas disease; CHAGAS-DISEASE; METABOLISM; CYTOCHROME-P450; NIFURTIMOX; THERAPY;

D O I：

10.1590/S0074-02762011000300021

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Benznidazole (Bz) exhibits toxic side effects in animal studies and clinical use. Reductive metabolism of Bz in liver microsomes modulates the duration of its chemotherapeutic effect and its toxicity. The rate of this metabolism depends on age and is less intense in newborns and youngsters than in adults. In the present study, we determined Bz blood levels in rats of different ages that received Bz intragastrically (100 mg/kg). We developed and validated a high-pressure liquid chromatography with UV detector method for determination of Bz levels in whole blood. Bz levels were significantly higher and persisted for longer periods of time in the blood of young rats when compared to that of adult animals.

引用

页码：374 / 377

页数：4

共 29 条

[1]

AGUILAR E, 1987, ARCH INT PHARMACOD T, V289, P11

[2] Mode of action of Nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: Is oxidative stress involved? [J].

Boiani, Mariana ;

Piacenza, Lucia ;

Hernandez, Paola ;

Boiani, Lucia ;

Cerecetto, Hugo ;

Gonzalez, Mercedes ;

Denicola, Ana .

BIOCHEMICAL PHARMACOLOGY, 2010, 79 (12) :1736-1745

[3]

CANÇADO J. Romeu, 2002, Rev. Inst. Med. trop. S. Paulo, V44, P29, DOI 10.1590/S0036-46652002000100006

[4]

Castro J A, 1988, Biomed Environ Sci, V1, P19

[5]

Castro J. A., 2008, B ATA, V22, P24

[6]

Castro JA, 2000, BIOMED ENVIRON SCI, V13, P271

[7] Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis) [J].

Castro, Jose A. ;

de Mecca, Maria Montalto ;

Bartel, Laura C. .

HUMAN & EXPERIMENTAL TOXICOLOGY, 2006, 25 (08) :471-479

[8] A critical review on Chagas disease chemotherapy [J].

Coura, JR ;

de Castro, SL .

MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2002, 97 (01) :3-24

[9]

DETORANZO EGD, 1988, EXPERIENTIA, V44, P880, DOI 10.1007/BF01941187

[10]

DETORANZO EGD, 1983, RES COMMUN CHEM PATH, V41, P341

← 1 2 3 →