Early detection and treatment of obstructive sleep apnoea in infants with Down syndrome: a prospective, non-randomised, controlled, interventional study

被引:4
作者
Fauroux, Brigitte [1 ,2 ]
Sacco, Silvia [3 ]
Couloigner, Vincent [4 ]
Amaddeo, Alessandro [1 ,2 ,5 ]
Prioux, Emmanuelle [3 ]
Toulas, Jeanne [3 ]
Luscan, Romain [4 ]
Clert, Manon [3 ]
Caillaud, Marie-Anne [3 ]
De Sanctis, Livio [1 ]
Khirani, Sonia [1 ,2 ,6 ]
Marey, Isabelle [3 ]
Mircher, Clotilde [3 ,6 ]
机构
[1] Hop Necker Enfants Malad, Assistance Publ Hop Paris AP HP, Pediat Noninvas Ventilat & Sleep Unit, F-75015 Paris, France
[2] Univ Paris Cite, Equipe Accueil EA VIFASOM, F-75004 Paris, France
[3] Inst Jerome Lejeune, Rue Volontaires, F-75015 Paris, France
[4] Hop Necker Enfants Malad, Assistance Publ Hop Paris AP HP, Head & Neck Surg, F-75015 Paris, France
[5] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, Trieste, Italy
[6] ASV Sante, Gennevilliers, France
来源
LANCET REGIONAL HEALTH-EUROPE | 2024年 / 45卷
关键词
Down syndrome; Polysomnography; Obstructive sleep apnoea; Neurocognitive function; Behaviour; AGE-CHILDREN; PREVALENCE; PRESCHOOL;
D O I
10.1016/j.lanepe.2024.101035
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background Infants with Down syndrome (DS) are at high risk of obstructive sleep apnoea (OSA) which is associated with neurocognitive dysfunction and behaviour problems. The aim of our study was to evaluate the effect of early OSA treatment in infants with DS on neurocognitive development and behaviour. Methods In this prospective, interventional, non-randomised study, 40 infants with DS underwent polysomnography (PSG) every 6 months in room air between 6 and 36 months of age ( Screened Group) ) and were compared to a control group of 40 infants with DS receiving standard of care and a single, systematic PSG in room air at 36 months of age ( Standard Care Group). ). When present, OSA was treated. The primary endpoint was the total score of the Griffiths fi ths Scales of Child Development, Third Edition (Griffiths i ths III) and its subscores at 36 months. Secondary endpoints included a battery of neurocognitive and behaviour questionnaires, and PSG outcomes. Findings On the Griffiths fi ths III, the total score was significantly fi cantly higher in the Screened Group compared to the Standard Care Group (difference: 4.1; 95%CI: 1.3; 7.6; p = 0.009). Results in Griffiths fi ths III subscores and secondary endpoints were in support of better neurocognitive outcomes in the Screened Group compared with the Standard Care Group. At 36 months, median (Q1; Q3) apnoea-hypopnea index was higher in the Standard Care Group (4.0 [1.5; 9.0] events/ hour) compared to the Screened Group (1.0 [1.0; 3.0] events/hour, p = 0.006). Moderate and severe OSA were more frequent in the Standard Care Group as compared to the Screened Group (18.9% versus 3.7% for moderate OSA and 27.0% versus 7.4% for severe OSA). Interpretation Early diagnosis and treatment of OSA in infants with DS may contribute to a significantly fi cantly better neurocognitive outcome and behaviour at the age of 36 months.
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页数:11
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