Biomarkers: How to consolidate them in clinical practice

An inadequate biomarker validation can affect many patients' diagnosis, treatment, and follow-up. Therefore, special interest should be placed on performing these analyses correctly so that biomarkers can be applicable to patients and evidence of their clinical usefulness can be generated. A methodological work on the concept of biomarkers is presented, as well as the difficulties associated with the methodological approach to their development, validation, and implementation in clinical practice. (c) 2024 Elsevier Espana, a, S.L.U. and Sociedad Espanola ola de Reumatolog & imath;<acute accent>a y Colegio Mexicano de Reumatolog & imath;<acute accent>a. All rights are reserved, including those for text and data mining, AI training, and similar technologies.