Carbapenem resistant Campylobacter jejuni bacteremia in a Bruton's X-linked agammaglobulinemia patient

被引：0

作者：

Zhuo, Ran ^{[1
]}

Younes, Ramee L. ^{[2
]}

Ward, Kevin ^{[1
]}

Yang, Shangxin ^{[1
]}

机构：

[1] Univ Calif Los Angeles, UCLA David Geffen Sch Med, Dept Pathol & Lab Med, 11633 San Vicente Blvd, Los Angeles, CA 90049 USA

[2] Univ Calif Los Angeles, UCLA David Geffen Sch Med, Div Infect Dis, Los Angeles, CA USA

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2024年 / 43卷 / 12期

关键词：

Carbapenem resistance; Campylobacter jejuni; OXA-61; Gene duplication; Porin mutation; Recurrent bloodstream infections; EFFLUX PUMP; EXPRESSION; MECHANISM; REPRESSOR; STRAINS; CMEABC;

D O I：

10.1007/s10096-024-04937-1

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Immunocompromised patients are prone to recurrent Campylobacter infections. We report a case of recurrent multi-drug resistant Campylobactor jejuni bloodstream infections in a Bruton's X-linked agammaglobulinemia patient with prolonged ertapenem treatment. The isolate from the fifth recurrence developed carbapenem resistance, which is associated with mutations in a porin gene porA, and promoter changes and duplication of chromosomal blaOXA-61 gene. Combination therapy using cefepime and doxycycline (later switched to moxifloxacin) cleared the infection.

引用

页码：2459 / 2463

页数：5

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