Glymphotherapeutics for Alzheimer's disease: Time to move the needle

被引：0

作者：

Mohanasundaram, Arunsundar ^{[1
]}

Mofatteh, Mohammad ^{[2
]}

Ashraf, Ghulam Md ^{[3
]}

Pratico, Domenico ^{[4
]}

机构：

[1] Sathyabama Inst Sci & Technol, Sch Pharm, Chennai 600119, Tamil Nadu, India

[2] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Belfast BT9 7BL, North Ireland

[3] Xian Jiaotong Liverpool Univ, Sch Sci, Dept Biol Sci, Suzhou 215123, Jiangsu, Peoples R China

[4] Temple Univ, Lewis Katz Sch Med, Dept Neurosci, Philadelphia, PA 19140 USA

来源：

AGEING RESEARCH REVIEWS | 2024年 / 101卷

关键词：

Alzheimer's disease; Dementia; Glymphatic clearance; Aquaporin-4; Glymphotherapeutics; Neurodegenerative disease; Neurotherapeutics; AQUAPORIN-4; LOCALIZATION; AQP4;

D O I：

10.1016/j.arr.2024.102478

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alzheimer's disease (AD), the most predominant neurodegenerative disease and a quintessential entity within the dementia umbrella, is a global public health crisis. While the lack of disease modifying therapies has been a weak point in AD treatment, the success of recently approved monoclonal antibody-based therapeutics (aducanumab and lecanemab) targeted at the removal of amyloid-beta (A beta) peptides in the brain is still under debate. There are multiple safety concerns about these approved neurotherapeutics including amyloid-related imaging abnormalities, stroke, meningitis, encephalitis, and even death. Novel paradigms focused on aquaporin-4mediated neuro-perivascular A beta and Tau protein clearance pathway are garnering attention. In this paper, we argue that orchestrating the drug discovery focused on glymphatic clearance-facilitating drugs ("glymphotherapeutics") might be a potentially novel and viable strategy to mitigate the progression and improve the clinical outcomes of AD.

引用

页数：4

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