Metformin and vitamin D combination therapy ameliorates type 2 diabetes mellitus-induced renal injury in male Wistar rats

被引:0
作者
Abdulrahim, Halimat Amin [1 ]
Odetayo, Adeyemi Fatai [2 ]
Owootori, Emmanuel Aduragbemi [3 ]
Bulus, Joshua Damrah [3 ]
Jimoh, Fatimoh Bolanle [3 ]
Gabriel, Emmanuel Oluwamuyiwa [3 ]
Odiete, Iyanu Feranmi [3 ]
Olayaki, Luqman Aribidesi [3 ]
机构
[1] Univ Ilorin, Dept Med Biochem, Ilorin, Nigeria
[2] Fed Univ Hlth Sci, Dept Physiol, Ila Orangun, Nigeria
[3] Univ Ilorin, Dept Physiol, Ilorin, Nigeria
关键词
Diabetes mellitus; Diabetic kidney disease; Electrolyte imbalance; Proton pump dysfunction; Vitamin D; CHRONIC KIDNEY-DISEASE; OXIDATIVE STRESS; D SUPPLEMENTATION; XANTHINE-OXIDASE; INFLAMMATION; METABOLISM; ACTIVATION; MODEL; DYSLIPIDEMIA; METAANALYSIS;
D O I
10.1007/s00210-024-03478-w
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Diabetic kidney disease is a major microvascular diabetes mellitus (DM) complication clinically associated with a gradual renal function decline. Although metformin is a common drug for managing DM, however, monotherapy treatment with any antidiabetic drug will necessitate dosage increment since type 2 DM (T2DM) deteriorates over time due to the increasing pancreatic beta-cell dysfunction and will eventually require a combination therapy approach with another antidiabetic medication. Vitamin D is a food supplement that has been proven to have antidiabetic and reno-protective activities. Hence, we explore the combination of vitamin D and metformin on T2DM-induced renal dysfunction. Thirty male Wistar rats were randomized into five (5) groups: control, diabetes untreated, diabetics treated with metformin, vitamin D, and vitamin D + metformin. Vitamin D and metformin significantly reversed DM-induced hyperglycemia, electrolyte imbalance, and dyslipidemia. Also, vitamin D and metformin reversed T2DM-induced increase in serum creatinine and urea and renal lactate, LDH, and oxido-inflammatory response. These observed alterations were accompanied by an increase in proton pump activities and modulation of Nrf2/Nf-kappa B and XO/UA signaling. This study revealed that vitamin D and/or metformin ameliorated T2DM-induced renal injury.
引用
收藏
页码:3133 / 3146
页数:14
相关论文
共 50 条
  • [21] Effects of vitamin D on blood pressure in patients with type 2 diabetes mellitus
    Lee, Kyeong Ju
    Lee, Yu Jeung
    INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS, 2016, 54 (04) : 233 - 242
  • [22] Identification of Probucol as a candidate for combination therapy with Metformin for Type 2 diabetes
    Guttapadu, Ranjitha
    Korla, Kalyani
    Uk, Safnaz
    Annam, Vamseedhar
    Ashok, Purnima
    Chandra, Nagasuma
    NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 2023, 9 (01)
  • [23] Insulin protects against type 1 diabetes mellitus-induced aortopathy associated with the inhibition of biomarkers of vascular injury in rats
    Bin-Jaliah, Ismaeel
    Hewett, Peter W.
    Al-Hashem, Fahaid
    Haidara, Mohamed A.
    Kader, Dina H. Abdel
    Morsy, M. D.
    Al-Ani, Bahjat
    ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 2021, 127 (03) : 266 - 272
  • [24] Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?
    Pittas, Anastassios G.
    Jorde, Rolf
    Kawahara, Tetsuya
    Dawson-Hughes, Bess
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (12)
  • [25] Vitamin D, Oxidative Stress and Glycaemic Control in Subjects with Type 2 Diabetes Mellitus: Systematic Review
    Roman-Casas, Mariana
    Valdes Ramos, Roxana
    Martinez-Carrillo, Beatriz E.
    Gaona Valle, Laura S.
    Perez Malpica, Itzelt
    CURRENT NUTRITION & FOOD SCIENCE, 2022, 18 (09) : 833 - 841
  • [26] Association of vitamin D levels and polymorphisms in vitamin D receptor with type 2 diabetes mellitus
    Alfaqih, Mahmoud A.
    Araidah, Abdullah
    Amarin, Zouhair
    Saadeh, Rami
    Al-shboul, Othman
    Khanfar, Mariam
    Allouh, Mohammed Z.
    BIOMEDICAL REPORTS, 2023, 18 (01)
  • [27] Amelioration of streptozotocin-induced type 2 diabetes mellitus in Wistar rats by arachidonic acid
    Gundala, Naveen K. V.
    Naidu, Vegi G. M.
    Das, Undurti N.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 496 (01) : 105 - 113
  • [28] Superimposed effect of ovariectomy on type 2 diabetes mellitus in Wistar rats
    Fahmy, Minerva K.
    Sayyed, Hayam G.
    Abd Elrahim, Eman A.
    Farag, Rana T. A.
    ALEXANDRIA JOURNAL OF MEDICINE, 2018, 54 (02) : 129 - 137
  • [29] Impact of vitamin D level on glycemic control in diabetes mellitus type 2 in Duhok
    Salih, Yosuf Abdullah
    Rasool, Mohammed T.
    Ahmed, Idris Haji
    Mohammed, Ayad Ahmad
    ANNALS OF MEDICINE AND SURGERY, 2021, 64
  • [30] Vitamin D diminishes the high platelet aggregation of type 2 diabetes mellitus patients
    Sultan, Maya
    Twito, Orit
    Tohami, Tali
    Ramati, Erez
    Neumark, Eran
    Rashid, Gloria
    PLATELETS, 2019, 30 (01) : 120 - 125