Collagen-hydroxyapatite based scaffolds for bone trauma and regeneration: recent trends and future perspectives

被引：0
作者：
Han, Dong [1 ]
Wang, Weijiao [2 ]
Gong, Jinpeng [1 ]
Ma, Yupeng [1 ]
Li, Yu [1 ]
机构：
[1] Yantaishan Hosp, Dept Trauma Orthoped, Yantai 264000, Peoples R China
[2] Yantaishan Hosp, Dept Otolaryngol, Yantai 264000, Peoples R China
来源：
NANOMEDICINE | 2024年 / 19卷 / 18-20期
关键词：
bone regeneration; collagen; drug delivery; ha/collagen composite; hydroxyapatite (HA); osteoconductivity; scaffolds; tissue engineering; COMPOSITE SCAFFOLDS; IN-VITRO; BIOACTIVE GLASS; GRAFT SUBSTITUTES; TISSUE; VIVO; NANOHYDROXYAPATITE; BIOCOMPATIBILITY; MINERALIZATION; ANTIBACTERIAL;
D O I：
10.1080/17435889.2024.2375958
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Regenerative therapy, a key area of tissue engineering, holds promise for restoring damaged organs, especially in bone regeneration. Bone healing is natural to the body but becomes complex under stress and disease. Large bone deformities pose significant challenges in tissue engineering. Among various methods, scaffolds are attractive as they provide structural support and essential nutrients for cell adhesion and growth. Collagen and hydroxyapatite (HA) are widely used due to their biocompatibility and biodegradability. Collagen and nano-scale HA enhance cell adhesion and development. Thus, nano HA/collagen scaffolds offer potential solutions for bone regeneration. This review focuses on the use and production of nano-sized HA/collagen composites in bone regeneration.
引用
收藏
页码：1689 / 1709
页数：21
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