Treatment of unresectable stage III non-small cell lung cancer for patients who are under-represented in clinical trials

被引：3

作者：

Bortolot, Martina ^{[1
,2
]}

Cortiula, Francesco ^{[2
,3
]}

Fasola, Gianpiero ^{[2
]}

De Ruysscher, Dirk ^{[3
]}

Naidoo, Jarushka ^{[4
,5
,6
]}

Hendriks, Lizza E. L. ^{[7
]}

机构：

[1] Univ Udine, Dept Med DAME, Udine, Italy

[2] Univ Hosp Udine, Dept Oncol, Piazzale Santa Maria Misericordia, I-33100 Udine, Italy

[3] Maastricht Univ, GROW Sch Oncol & Reprod, Dept Radiat Oncol Maastro, Med Ctr, Maastricht, Netherlands

[4] Beaumont Hosp, Dublin, Ireland

[5] RCSI Univ Hlth Sci, Dublin, Ireland

[6] Johns Hopkins Univ, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA

[7] Maastricht Univ, GROW Sch Oncol & Reprod, Dept Pulm Dis, Med Ctr, Maastricht, Netherlands

来源：

CANCER TREATMENT REVIEWS | 2024年 / 129卷

关键词：

NSCLC; Unresectable stage III; Special populations; Elderly; Frail; Comorbidities; PREDICTING RADIATION PNEUMONITIS; REAL-WORLD DATA; CONCURRENT CHEMORADIOTHERAPY; ELDERLY-PATIENTS; OLDER PATIENTS; RADIOTHERAPY; THERAPY; DURVALUMAB; NSCLC; CHEMORADIATION;

D O I：

10.1016/j.ctrv.2024.102797

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Concurrent chemoradiotherapy (cCRT) followed by one year of consolidation durvalumab is the current standard-of-care for patients with unresectable stage III non-small cell lung cancer (NSCLC), of good functional status. However, cCRT and consolidation durvalumab may be challenging to administer for selected patient populations underrepresented or even excluded in clinical trials: older and/or frail patients; those with cardiovascular or respiratory comorbidities in which treatment-related adverse events may be higher, and patients with pre-existing autoimmune disorders for whom immunotherapy use is controversial. In this narrative review, we discuss the current evidence, challenges, ongoing clinical trials and potential future treatment scenarios in relevant subgroups of patients with locally advanced NSCLC, who are underrepresented in clinical trials.

引用

页数：9

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