A Randomized Comparison of Postprandial Glucose Excursion Using Inhaled Insulin Versus Rapid-Acting Analog Insulin in Adults With Type 1 Diabetes Using Multiple Daily Injections of Insulin or Automated Insulin Delivery

被引：9

作者：

Hirsch, Irl B. ^{[1
]}

Beck, Roy W. ^{[2
]}

Marak, Martin Chase ^{[2
]}

Calhoun, Peter ^{[2
]}

Manessis, Adham ^{[3
]}

Salhin, Amna ^{[4
]}

Manessis, Anastasios ^{[5
]}

Coviello, Andrea D. ^{[6
]}

Bhargava, Anuj ^{[7
]}

Thorsell, Ashley ^{[8
]}

Castillo, Astrid Atakov ^{[9
]}

Bode, Bruce W. ^{[10
]}

Levister, Camilla ^{[11
]}

Levy, Carol J. ^{[11
]}

Donahue, Cassandra ^{[6
]}

Cordero, Christian ^{[12
]}

Beatson, Christie ^{[13
]}

Langel, Christine R. ^{[7
]}

Jacobson, Christopher ^{[12
]}

Kurek, Corey ^{[14
]}

Cruse, Dana ^{[15
]}

Pickering, David ^{[15
]}

Tamarez, Denisa ^{[11
]}

Steenkamp, Devin W. ^{[9
]}

Desjardins, Donna ^{[14
]}

Aleppo, Grazia ^{[16
]}

O'Malley, Grenye ^{[11
]}

Akturk, Halis K. ^{[13
]}

Diner, Jamie ^{[6
]}

Baran, Jesica D. ^{[1
]}

Buse, John B. ^{[6
]}

Ruedy, Katrina ^{[2
]}

Codorniz, Kevin ^{[12
]}

Klein, Klara R. ^{[6
]}

Castorino, Kristin ^{[8
]}

Jordan, Lin Fan ^{[17
]}

Kipnes, Mark ^{[4
]}

Church, Mei Mei ^{[8
]}

Hamdy, Osama ^{[3
]}

Raskin, Philip ^{[17
]}

Nguyen, Quang T. ^{[18
]}

Weinstock, Ruth S. ^{[19
]}

Lee, Scott ^{[12
]}

Rizvi, Shafaq ^{[14
]}

Bzdick, Suzan ^{[9
]}

Rodriguez, Tahereh Ghorbani ^{[6
]}

Salah, Tareq ^{[3
]}

Blevins, Thomas ^{[20
]}

Kudva, Yogish C. ^{[14
]}

Haider, Zehra ^{[13
]}

机构：

[1] Univ Washington, Seattle, WA USA

[2] Jaeb Ctr Hlth Res, Tampa, FL 33647 USA

[3] Joslin Diabet Ctr, Boston, MA USA

[4] Diabet & Glandular Dis Clin, San Antonio, TX USA

[5] NYC Res Inc, Long Isl City, NY USA

[6] Univ N Carolina, Chapel Hill, NC USA

[7] Iowa Diabet & Endocrinol Res Ctr, W Des Moines, IA USA

[8] Sansum Diabet Res Inst, Santa Barbara, CA USA

[9] Boston Med Ctr, Boston, MA USA

[10] Atlanta Diabet Associates, Atlanta, GA USA

[11] Icahn Sch Med Mt Sinai, New York, NY USA

[12] Loma Linda Univ, Loma Linda, CA USA

[13] Barbara Davis Ctr Childhood Diabet, Denver, CO USA

[14] Mayo Clin, Rochester, MN USA

[15] Mt State Diabet, Parkersburg, WV USA

[16] Northwestern Univ, Chicago, IL USA

[17] Univ Texas Southwestern, Dallas, TX USA

[18] Las Vegas Endocrinol, Henderson, NV USA

[19] SUNY Upstate Med Univ, Syracuse, NY USA

[20] Texas Diabet & Endocrinol, Austin, TX USA

来源：

DIABETES CARE | 2024年 / 47卷 / 09期

关键词：

D O I：

10.2337/dc24-0838

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE To compare postprandial glucose excursions following a bolus with inhaled technosphere insulin (TI) or subcutaneous rapid-acting analog (RAA) insulin. RESEARCH DESIGN AND METHODS A meal challenge was completed by 122 adults with type 1 diabetes who were using multiple daily injections (MDI), a nonautomated pump, or automated insulin delivery (AID) and who were randomized to bolus with their usual RAA insulin (n = 61) or TI (n = 61). RESULTS The primary outcome, the treatment group difference in area under the curve for glucose >180 mg/dL over 2 h, was less with TI versus RAA (adjusted difference -12 mg/dL, 95% CI -22 to -2, P = 0.02). With TI, the glucose excursion was smaller (P = 0.01), peak glucose lower (P = 0.01), and time to peak glucose shorter (P = 0.006). Blood glucose <70 mg/dL occurred in one participant in each group. CONCLUSIONS Postmeal glucose excursion was smaller with TI than with RAA insulin in a cohort that included both AID and MDI users.

引用

页码：1682 / 1687

页数：7

共 4 条

[1] Rethinking the Viability and Utility of Inhaled Insulin in Clinical Practice [J].

Heinemann, Lutz ;

Parkin, Christopher G. .

JOURNAL OF DIABETES RESEARCH, 2018, 2018

[2]

Heinemann Lutz, 2017, J Diabetes Sci Technol, V11, P148, DOI [10.1177/1932296816658055, 10.1177/1932296816658055]

[3]

Kaiserman K, 2023, DIABETES TECHNOL THE, V25, pA72

[4]

Kaiserman Kevin B, 2024, J Diabetes Sci Technol, V18, P397, DOI [10.1177/19322968221110622, 10.1177/19322968221110622]

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