Translational Research Platform for Malignant Central Nervous System Tumors

被引：0
作者：
Ateishi, Kensuke [1 ,2 ,3 ]
机构：
[1] Yokohama City Univ, Grad Sch Med, Dept Neurosurg, Yokohama, Kanagawa, Japan
[2] Yokohama City Univ, Grad Sch Med Sci, Lab Biopharmaceut & Regenerat Sci, Yokohama, Japan
[3] Yokohama City Univ, Neurosurg Oncol Lab, Yokohama, Kanagawa, Japan
来源：
NEUROLOGIA MEDICO-CHIRURGICA | 2024年 / 64卷 / 09期
关键词：
central nervous system tumors; translational research; precision medicine; ADJUVANT TEMOZOLOMIDE; GENOMIC ANALYSIS; LOW-GRADE; IDH1; GLIOMA; MUTATIONS; CLASSIFICATION; GLIOBLASTOMA; RADIOTHERAPY; CONCOMITANT;
D O I：
10.2176/jns-nmc.2024-0078
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Some central nervous system (CNS) malignancies are highly aggressive and urgently need innovative treatment strategies to improve prognosis. A significant concern for therapeutic development is the time-consuming nature of developing treatments for CNS tumors. Therefore, a rapid and efficient translational approach is needed to address this problem. Translational and reverse translational research aims to bridge the gap between laboratory data and clinical applications and has been developed in the field of neuro-oncology. This study presents our translational platform systems for malignant CNS tumors, which combine an intraoperative integrated diagnostic system and comprehensive in vitro and in vivo assay systems. These laboratory systems may contribute to a better understanding of tumor biology and the development of novel therapeutic strategies for the poor prognosis of CNS tumors.
引用
收藏
页码：323 / 329
页数：7
相关论文
共 42 条
  • [1] Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
    Brat, Daniel J.
    Verhaak, Roel G. W.
    Al-dape, Kenneth D.
    Yung, W. K. Alfred
    Salama, Sofie R.
    Cooper, Lee A. D.
    Rheinbay, Esther
    Miller, C. Ryan
    Vitucci, Mark
    Morozova, Olena
    Robertson, A. Gordon
    Noushmehr, Houtan
    Laird, Peter W.
    Cherniack, Andrew D.
    Akbani, Rehan
    Huse, Jason T.
    Ciriello, Giovanni
    Poisson, Laila M.
    Barnholtz-Sloan, Jill S.
    Berger, Mitchel S.
    Brennan, Cameron
    Colen, Rivka R.
    Colman, Howard
    Flanders, Adam E.
    Giannini, Caterina
    Grifford, Mia
    Iavarone, Antonio
    Jain, Rajan
    Joseph, Isaac
    Kim, Jaegil
    Kasaian, Katayoon
    Mikkelsen, Tom
    Murray, Bradley A.
    O'Neill, Brian Patrick
    Pachter, Lior
    Parsons, Donald W.
    Sougnez, Carrie
    Sulman, Erik P.
    Vandenberg, Scott R.
    Van Meir, Erwin G.
    von Deimling, Andreas
    Zhang, Hailei
    Crain, Daniel
    Lau, Kevin
    Mallery, David
    Morris, Scott
    Paulauskis, Joseph
    Penny, Robert
    Shelton, Troy
    Sherman, Mark
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2015, 372 (26) : 2481 - 2498
  • [2] The Somatic Genomic Landscape of Glioblastoma
    Brennan, Cameron W.
    Verhaak, Roel G. W.
    McKenna, Aaron
    Campos, Benito
    Noushmehr, Houtan
    Salama, Sofie R.
    Zheng, Siyuan
    Chakravarty, Debyani
    Sanborn, J. Zachary
    Berman, Samuel H.
    Beroukhim, Rameen
    Bernard, Brady
    Wu, Chang-Jiun
    Genovese, Giannicola
    Shmulevich, Ilya
    Barnholtz-Sloan, Jill
    Zou, Lihua
    Vegesna, Rahulsimham
    Shukla, Sachet A.
    Ciriello, Giovanni
    Yung, W. K.
    Zhang, Wei
    Sougnez, Carrie
    Mikkelsen, Tom
    Aldape, Kenneth
    Bigner, Darell D.
    Van Meir, Erwin G.
    Prados, Michael
    Sloan, Andrew
    Black, Keith L.
    Eschbacher, Jennifer
    Finocchiaro, Gaetano
    Friedman, William
    Andrews, David W.
    Guha, Abhijit
    Iacocca, Mary
    O'Neill, Brian P.
    Foltz, Greg
    Myers, Jerome
    Weisenberger, Daniel J.
    Penny, Robert
    Kucherlapati, Raju
    Perou, Charles M.
    Hayes, D. Neil
    Gibbs, Richard
    Marra, Marco
    Mills, Gordon B.
    Lander, Eric
    Spellman, Paul
    Wilson, Richard
    [J]. CELL, 2013, 155 (02) : 462 - 477
  • [3] Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    Dang, Lenny
    White, David W.
    Gross, Stefan
    Bennett, Bryson D.
    Bittinger, Mark A.
    Driggers, Edward M.
    Fantin, Valeria R.
    Jang, Hyun Gyung
    Jin, Shengfang
    Keenan, Marie C.
    Marks, Kevin M.
    Prins, Robert M.
    Ward, Patrick S.
    Yen, Katharine E.
    Liau, Linda M.
    Rabinowitz, Joshua D.
    Cantley, Lewis C.
    Thompson, Craig B.
    Heiden, Matthew G. Vander
    Su, Shinsan M.
    [J]. NATURE, 2009, 462 (7274) : 739 - U52
  • [4] Intraoperative Integrated Diagnostic System for Malignant Central Nervous System Tumors
    Hayashi, Takahiro
    Tateishi, Kensuke
    Matsuyama, Shinichiro
    Iwashita, Hiromichi
    Miyake, Yohei
    Oshima, Akito
    Honma, Hirokuni
    Sasame, Jo
    Takabayashi, Katsuhiro
    Sugino, Kyoka
    Hirata, Emi
    Udaka, Naoko
    Matsushita, Yuko
    Kato, Ikuma
    Hayashi, Hiroaki
    Nakamura, Taishi
    Ikegaya, Naoki
    Takayama, Yutaro
    Sonoda, Masaki
    Oka, Chihiro
    Sato, Mitsuru
    Isoda, Masataka
    Kato, Miyui
    Uchiyama, Kaho
    Tanaka, Tamon
    Muramatsu, Toshiki
    Miyake, Shigeta
    Suzuki, Ryosuke
    Takadera, Mutsumi
    Tatezuki, Junya
    Ayabe, Junichi
    Suenaga, Jun
    Matsunaga, Shigeo
    Miyahara, Kosuke
    Manaka, Hiroshi
    Murata, Hidetoshi
    Yokoyama, Takaakira
    Tanaka, Yoshihide
    Shuto, Takashi
    Ichimura, Koichi
    Kato, Shingo
    Yamanaka, Shoji
    Cahill, Daniel P.
    Fujii, Satoshi
    Shankar, Ganesh M.
    Yamamoto, Tetsuya
    [J]. CLINICAL CANCER RESEARCH, 2024, 30 (01) : 116 - 126
  • [5] Molecular and clinical diversity in primary central nervous system lymphoma
    Hernandez-Verdin, I.
    Kirasic, E.
    Wienand, K.
    Mokhtari, K.
    Eimer, S.
    Loiseau, H.
    Rousseau, A.
    Paillassa, J.
    Ahle, G.
    Lerintiu, F.
    Uro-Coste, E.
    Oberic, L.
    Figarella-Branger, D.
    Chinot, O.
    Gauchotte, G.
    Taillandier, L.
    Marolleau, J. -P.
    Polivka, M.
    Adam, C.
    Ursu, R.
    Schmitt, A.
    Barillot, N.
    Nichelli, L.
    Lozano-Sanchez, F.
    Ibanez-Julia, M. -J.
    Peyre, M.
    Mathon, B.
    Abada, Y.
    Charlotte, F.
    Davi, F.
    Stewart, C.
    de Reynies, A.
    Choquet, S.
    Soussain, C.
    Houillier, C.
    Chapuy, B.
    Hoang-Xuan, K.
    Alenorn, A.
    [J]. ANNALS OF ONCOLOGY, 2023, 34 (02) : 186 - 199
  • [6] Interactive Effects of Molecular, Therapeutic, and Patient Factors on Outcome of Diffuse Low-Grade Glioma
    Hervey-Jumper, Shawn L.
    Zhang, Yalan
    Phillips, Joanna J.
    Morshed, Ramin A.
    Young, Jacob S.
    McCoy, Lucie
    Lafontaine, Marisa
    Luks, Tracy
    Ammanuel, Simon
    Kakaizada, Sofia
    Egladyous, Andrew
    Gogos, Andrew
    Villanueva-Meyer, Javier
    Shai, Anny
    Warrier, Gayathri
    Rice, Terri
    Crane, Jason
    Wrensch, Margaret
    Wiencke, John K.
    Daras, Mariza
    Oberheim Bush, Nancy Ann
    Taylor, Jennie W.
    Butowski, Nicholas
    Clarke, Jennifer
    Chang, Susan
    Chang, Edward
    Aghi, Manish
    Theodosopoulos, Philip
    McDermott, Michael
    Jakola, Asgeir S.
    Kavouridis, Vasileios K.
    Nawabi, Noah
    Solheim, Ole
    Smith, Timothy
    Berger, Mitchel S.
    Molinaro, Annette M.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (11) : 2029 - +
  • [7] Molecular Genetic Profile of 300 Japanese Patients with Diffuse Gliomas Using a Glioma-tailored Gene Panel
    Higa, Nayuta
    Akahane, Toshiaki
    Yokoyama, Seiya
    Yonezawa, Hajime
    Uchida, Hiroyuki
    Fujio, Shingo
    Kirishima, Mari
    Takigawa, Kosuke
    Hata, Nobuhiro
    Toh, Keita
    Yamamoto, Junkoh
    Hanaya, Ryosuke
    Tanimoto, Akihide
    Yoshimoto, Koji
    [J]. NEUROLOGIA MEDICO-CHIRURGICA, 2022, : 391 - 399
  • [8] Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas
    Lassaletta, Alvaro
    Zapotocky, Michal
    Mistry, Matthew
    Ramaswamy, Vijay
    Honnorat, Marion
    Krishnatry, Rahul
    Stucklin, Ana Guerreiro
    Zhukova, Nataliya
    Arnoldo, Anthony
    Ryall, Scott
    Ling, Catriona
    McKeown, Tara
    Loukides, Jim
    Cruz, Ofelia
    de Torres, Carmen
    Ho, Cheng-Ying
    Packer, Roger J.
    Tatevossian, Ruth
    Qaddoumi, Ibrahim
    Harreld, Julie H.
    Dalton, James D.
    Mulcahy-Levy, Jean
    Foreman, Nicholas
    Karajannis, Matthias A.
    Wang, Shiyang
    Snuderl, Matija
    Rao, Amulya Nageswara
    Giannini, Caterina
    Kieran, Mark
    Ligon, Keith L.
    Garre, Maria Luisa
    Nozza, Paolo
    Mascelli, Samantha
    Raso, Alessandro
    Mueller, Sabine
    Nicolaides, Theodore
    Silva, Karen
    Perbet, Romain
    Vasiljevic, Alexandre
    Conter, Cecile Faure
    Frappaz, Didier
    Leary, Sarah
    Crane, Courtney
    Chan, Aden
    Ng, Ho-Keung
    Shi, Zhi-Feng
    Mao, Ying
    Finch, Elizabeth
    Eisenstat, David
    Wilson, Bev
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (25) : 2934 - +
  • [9] The 2007 WHO classification of tumours of the central nervous system (vol 114, pg 97, 2007)
    Louis, David N.
    Ohgaki, Hiroko
    Wiestler, Otmar D.
    Cavenee, Webster K.
    Burger, Peter C.
    Jouvet, Anne
    Scheithauer, Bernd W.
    Kleihues, Paul
    [J]. ACTA NEUROPATHOLOGICA, 2007, 114 (05) : 547 - 547
  • [10] The 2021 WHO Classification of Tumors of the Central Nervous System: a summary
    Louis, David N.
    Perry, Arie
    Wesseling, Pieter
    Brat, Daniel J.
    Cree, Ian A.
    Figarella-Branger, Dominique
    Hawkins, Cynthia
    Ng, H. K.
    Pfister, Stefan M.
    Reifenberger, Guido
    Soffietti, Riccardo
    von Deimling, Andreas
    Ellison, David W.
    [J]. NEURO-ONCOLOGY, 2021, 23 (08) : 1231 - 1251
12345