Immunomodulatory Roles of IL-15 in Immune Cells and its Potential for Cancer Immunotherapy

被引：3

作者：

Liu, Youhan ^{[1
]}

Ma, Wen ^{[1
]}

Tian, Xuewen ^{[1
]}

Wang, Qinglu ^{[1
]}

Lu, Xin ^{[1
]}

Luo, Ying ^{[2
]}

Xv, Jun ^{[1
]}

机构：

[1] Shandong Sport Univ, Grad Sch Educ, Jinan 250102, Peoples R China

[2] Zibo Cent Hosp, Dept Clin Lab, Zibo 255000, Peoples R China

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2024年 / 24卷 / 20期

关键词：

Tumor; NK; CD8+T; B cell; IL-15; natural killer; NATURAL-KILLER-CELLS; CD8(+) T-CELLS; LARGE ESTABLISHED TUMORS; ALPHA-CHAIN; B-CELLS; HOMEOSTATIC PROLIFERATION; HUMAN INTERLEUKIN-15; GROWTH-FACTOR; EXPRESSION; NK;

D O I：

10.2174/0118715206321574240821112747

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interleukin-15 (IL-15) was identified in 1994 as a T-cell growth factor with the capability to mimic the functions of IL-2. IL-15 engages with the IL-15R alpha subunit expressed on the surface of antigen-presenting cells (APCs) and, through a trans-presentation mechanism, activates the IL-2/IL-15R beta gamma complex receptor on the surface of natural killer (NK) cells and CD8+ T cells. This interaction initiates a cascade of downstream signaling pathways, playing a pivotal role in the activation, proliferation, and anti-apoptotic processes in NK cells, CD8+ T cells, and B cells. It provides a substantial theoretical foundation and potential therapeutic targets for tumor immunotherapy. Whether through active or passive immunotherapeutic strategies, IL-15 has emerged as a critical molecule for stimulating anti-tumor cell proliferation.

引用

页码：1457 / 1466

页数：10

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