Visible Light-Induced Electron-Donor-Acceptor-Mediated C-3 Coupling of Quinoxalin-2(1H)-ones with Unactivated Aryl Iodides

被引：5

作者：

Singh, Nihal ^{[1
]}

Sharma, Anoop ^{[1
]}

Singh, Jitender ^{[1
]}

Pandey, Amar Prakash ^{[1
]}

Sharma, Anuj ^{[1
]}

机构：

[1] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttarakhand, India

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 30期

关键词：

C-H ARYLATION; DECARBOXYLATIVE ACYLATION; ACYL PEROXIDES; METAL; QUINOXALINONES; PHOTOCATALYST; SALTS; QUINOXALIN-2(H)-ONES; 3-ARYLATION; AMINATION;

D O I：

10.1021/acs.orglett.4c02296

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Visible light-induced C-3 arylation of quinoxalin-2(1H)-ones with abundantly available aryl iodides with good yields via an electron-donor-acceptor (EDA)-complex formation have been accomplished. The radical scavenging, Electron paramagnetic resonance (EPR), UV-visible experiments, density functional theory (DFT), and quantum yield studies revealed that the reaction went through a radical pathway via a single electron transfer (SET) process. Furthermore, the protocol could also be applied to the synthesis of biologically active molecules, illustrating the practicality of the present protocol.

引用

页码：6471 / 6476

页数：6

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