The Changes of Mitochondria during Aging and Regeneration

被引：0

作者：

Li, Anqi ^{[1
,2
]}

Qin, Yuan ^{[1
]}

Gong, Guohua ^{[1
,2
]}

机构：

[1] Wenzhou Med Univ, Sch Lab Med & Life Sci, Key Lab Lab Med, Minist Educ, Wenzhou 325035, Peoples R China

[2] Tongji Univ, Shanghai East Hosp, Inst Regenerat Med, Sch Life Sci & Technol, Shanghai 200092, Peoples R China

来源：

ADVANCED BIOLOGY | 2024年 / 8卷 / 10期

基金：

中国国家自然科学基金;

关键词：

mtROS; mitochondrial homeostasis; mitochondrial oxidative respiration; regeneration; senescence; CELL-CYCLE PROGRESSION; DYNAMICS; ROS; SENESCENCE; EXPRESSION; MITOPHAGY; MUSCLE; ACTIVATION; AUTOPHAGY; GENE;

D O I：

10.1002/adbi.202300445

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Aging and regeneration are opposite cellular processes. Aging refers to progressive dysfunction in most cells and tissues, and regeneration refers to the replacement of damaged or dysfunctional cells or tissues with existing adult or somatic stem cells. Various studies have shown that aging is accompanied by decreased regenerative abilities, indicating a link between them. The performance of any cellular process needs to be supported by the energy that is majorly produced by mitochondria. Thus, mitochondria may be a link between aging and regeneration. It should be interesting to discuss how mitochondria behave during aging and regeneration. The changes of mitochondria in aging and regeneration discussed in this review can provide a timely and necessary study of the causal roles of mitochondrial homeostasis in longevity and health. Aging and regeneration are opposite cellular processes. Mitochondria as the energy plant not only generates ATP but also participates in many cellular activities. Thus, the changes in mitochondria may be a link between aging and regeneration. image

引用

页数：14

共 148 条

[91] Regulation of mitochondrial activity controls the duration of skeletal muscle regeneration in response to injury [J].