The prognostic value of the systemic immune inflammation index in patients with IgA nephropathy

被引:1
|
作者
Zhai, Yaling [1 ,2 ]
Sun, Shuaigang [1 ,2 ]
Zhang, Wenhui [1 ,2 ]
Tian, Huijuan [1 ,2 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Nephrol, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Renal Res Inst, Zhengzhou, Peoples R China
基金
中国博士后科学基金;
关键词
IgA nephropathy; systemic immune inflammation index; end-stage kidney disease; prognosis; LYMPHOCYTE RATIO; COMPLEMENT; PLATELET; MARKERS;
D O I
10.1080/0886022X.2024.2381613
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Background Immune and inflammatory factors are considered the basic underlying mechanisms of IgA nephropathy (IgAN). The systemic immune inflammation index (SII) is a new inflammatory biomarker and has been identified as a prognostic indicator for various diseases. However, limited studies have been conducted on the prognostic value of the SII in patients with IgAN, and we aimed to address this gap. Methods A total of 374 patients with IgAN confirmed by renal biopsy performed from 1 January 2015 to 1 April 2019, were retrospectively included. The follow-up period of all patients was at least 12 months after diagnosis, and the endpoint was defined as end-stage kidney disease (ESKD). Patients were further divided into a high-risk group (SII >= 456.21) and a low-risk group (SII < 456.21) based on the optimal cutoff value of the SII determined by receiver operating characteristic (ROC) curve analysis. Baseline clinicopathological parameters were compared between the groups, and Cox proportional hazards analyses and Kaplan-Meier analysis were performed to assess renal survival in IgAN patients. Results After a median follow-up period of 32.5 months, a total of 53 patients eventually reached ESKD. Patients in the high-SII group tended to have a lower hemoglobin level (p = 0.032) and eGFR (p < 0.001), a higher serum creatinine level (p = 0.023) and 24-hour total protein level (p = 0.004), more severe tubular atrophy and interstitial fibrosis (p = 0.002) and more crescents (p = 0.030) than did those in the low-SII group. Univariate and multivariate Cox regression analyses demonstrated that an SII >= 456.21 was an independent risk factor for poor renal survival in IgAN patients (HR 3.028; 95% CI 1.486-6.170; p = 0.002). Kaplan-Meier analysis revealed that a high SII was significantly associated with poor renal prognosis (p < 0.001) and consistently exhibited remarkable discriminatory ability across different subgroups in terms of renal survival. Conclusion A high SII was associated with more severe baseline clinical and pathological features, and an SII >= 456.21 was an independent risk factor for progression to ESKD in IgAN patients.
引用
收藏
页数:8
相关论文
共 50 条
  • [1] Prognostic value of systemic immune inflammation index in patients with laryngeal cancer
    Atasever Akkas, Ebru
    Yucel, Birsen
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2021, 278 (06) : 1945 - 1955
  • [2] Prognostic value of prognostic nutritional index and systemic immune-inflammation index in patients with osteosarcoma
    Huang, Xin
    Hu, Hongzhi
    Zhang, Weiyue
    Shao, Zengwu
    JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (10) : 18408 - 18414
  • [3] Systemic immune inflammation index and pan-immune inflammation value as prognostic markers in patients with idiopathic low and moderate risk membranous nephropathy
    Kazan, D. E.
    Kazan, S.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2023, 27 (02) : 642 - 648
  • [4] Prognostic value of systemic immune-inflammation index in patients with gastric cancer
    Kang Wang
    Feiyu Diao
    Zhijun Ye
    Xinhua Zhang
    Ertao Zhai
    Hui Ren
    Tong Li
    Hui Wu
    Yulong He
    Shirong Cai
    Jianhui Chen
    Chinese Journal of Cancer, 2017, 36 (09) : 420 - 426
  • [5] Prognostic value of systemic immune-inflammation index in patients with gastric cancer
    Wang, Kang
    Diao, Feiyu
    Ye, Zhijun
    Zhang, Xinhua
    Zhai, Ertao
    Ren, Hui
    Li, Tong
    Wu, Hui
    He, Yulong
    Cai, Shirong
    Chen, Jianhui
    CHINESE JOURNAL OF CANCER, 2017, 36
  • [6] Prognostic value of the systemic immune-inflammation index, systemic inflammation response index, and prognostic nutritional index in head and neck cancer
    Akkas, Ebru Atasever
    Erdis, Eda
    Yucel, Birsen
    EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2023, 280 (08) : 3821 - 3830
  • [7] Prognostic value of the systemic immune-inflammation index, systemic inflammation response index, and prognostic nutritional index in head and neck cancer
    Ebru Atasever Akkas
    Eda Erdis
    Birsen Yucel
    European Archives of Oto-Rhino-Laryngology, 2023, 280 : 3821 - 3830
  • [8] Prognostic value of systemic immune-inflammation index in patients with chronic heart failure
    Seo, M.
    Yamada, T.
    Morita, T.
    Furukawa, Y.
    Tamaki, S.
    Iwasaki, Y.
    Kawasaki, M.
    Kikuchi, A.
    Kawai, T.
    Ikeda, I.
    Fukuhara, E.
    Nakamura, J.
    Abe, M.
    Fukunami, M.
    EUROPEAN HEART JOURNAL, 2018, 39 : 70 - 71
  • [9] Prognostic Value of Preoperative Systemic Immune-Inflammation Index in Patients with Cervical Cancer
    Huaping Huang
    Qin Liu
    Lixia Zhu
    Yan Zhang
    Xiaojuan Lu
    Yawei Wu
    Li Liu
    Scientific Reports, 9
  • [10] Prognostic Value of the Pretreatment Systemic Immune-Inflammation Index in Patients with Colorectal Cancer
    Li, Jing
    Shao, Jingjing
    Zhang, Xunlei
    Chen, Xin
    Zhao, Wenjing
    Qian, Hongyan
    Cui, Xiaopeng
    Jiang, Xiaohui
    GASTROENTEROLOGY RESEARCH AND PRACTICE, 2020, 2020