Effectiveness of Tofacitinib in Patients With Ulcerative Colitis: A Nationwide Veterans Administration Cohort Study

被引：2

作者：

Khan, Nabeel ^{[1
,2
]}

Sundararajan, Ramaswamy ^{[1
]}

Patel, Manthankumar ^{[1
]}

Trivedi, Chinmay ^{[1
]}

Yang, Yu-Xiao ^{[1
,2
,3
]}

机构：

[1] Corporal Michael J Crescenz VA Med Ctr, Dept Gastroenterol, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA

[3] Univ Penn, Perelman Sch Med, Dept Biostat Epidemiol & Informat, Philadelphia, PA USA

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2024年 / 119卷 / 08期

关键词：

ulcerative colitis; tofacitinib; effectiveness; INFLAMMATORY-BOWEL-DISEASE;

D O I：

10.14309/ajg.0000000000002761

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION: There is paucity of data on the effectiveness and safety of tofacitinib among elderly patients with ulcerative colitis (UC). METHODS: Through a retrospective cohort study among the US National Veterans Affairs Healthcare System, we evaluated effectiveness among the elderly (>= 65) and young (<65) patients with UC initiated on tofacitinib. RESULTS: Among 158 patients (53 elderly, 105 young), effectiveness at 12 months was 50.94% in the elderly and 33.33% in the young (P = 0.032). DISCUSSION: In a nationwide cohort of patients with UC initiating tofacitinib, effectiveness was seen in half of the elderly patients.

引用

页码：1632 / 1635

页数：4

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