Intravesical Bacille Calmette-Guerin (BCG) Vaccine Affects Cognition

被引：0

作者：

Greenblatt, Charles L. ^{[1
]}

Bercovier, Herve ^{[1
]}

Klein, Benjamin Y. ^{[2
]}

Gofrit, Ofer N. ^{[3
]}

机构：

[1] Hebrew Univ Jerusalem, Inst Med Res Israel Canada IMRIC, Dept Microbiol & Mol Genet, POB 12272, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, Jerusalem, Israel

[3] Hadassah Hebrew Univ, Dept Urol, Med Ctr, Jerusalem, Israel

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2024年 / 100卷 / 03期

关键词：

Alzheimer's disease; bacille Calmette-Guerin; cognition; Montreal Cognitive Assessment; vaccines;

D O I：

10.3233/JAD-240307

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Montreal Cognitive Assessment (MoCA) is a valuable assessment of the patient's awareness of time and place. We show that bacille Calmette-Guerin (BCG) significantly affects MoCA testing when administered by the intravesical route. MoCA scores were lower with increasing age and higher in more formally educated individuals. Patients receiving BCG tended to maintain their MoCA scores, whereas almost half the control cases tended to show reduced scores. This benefit is supported by reduced pre-amyloid biomarkers in BCG-injected healthy volunteers and a favorable effect on neuronal dendritic development in animal models. Our results suggest that BCG has a beneficial impact on the cognitive status of older individuals.

引用

页码：771 / 774

页数：4

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